p53 anticorps (AA 50-100)

N° du produit ABIN7448707

Cet anticorps Lapin Polyclonal détecte spécifiquement p53 dans IHC. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour p53 anticorps (AA 50-100) (ABIN7448707)

Antigène: p53 (TP53) (Tumor Protein P53 (TP53))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp p53 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-p53 anticorps

Épitope: AA 50-100

Fonction: Rabbit anti-p53 IHC Antibody, Affinity Purified

Homologie: Gorilla,Chimpanzee,Common tree shrew

Purification: Affinity Purified

Immunogène: Between AA 50 and 100

Isotype: IgG

Information d'application

Indications d'application: 1:100 - 1:500

Restrictions: For Research Use only

Stockage

Concentration: 100 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur p53

Antigène: p53 (TP53) (Tumor Protein P53 (TP53))

Autre désignation: p53

Sujet: Background: p53 is a tumor suppressor protein that is mutated or inactivated in over 50 % of human cancers. Loss of function defects in p53 are the cause of the autosomal dominant familial cancer syndrome, Li-Fraumeni syndrome (LFS) that is characterized by the development of a diverse set of malignancies at very early ages. At the cellular level p53 is involved in the negative regulation of cell the cycle via its transactivational control of genes required for cell cycle progression. Depending on the physiological circumstance, p53 can promote growth arrest or apoptosis.

ID gène: 7157

NCBI Accession: NP_000537

UniProt: P04637

Pathways: Signalisation p53, Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, L'effet Warburg