ERCC3 anticorps (AA 575-625)

N° du produit ABIN7454400

Cet anticorps Lapin Polyclonal détecte spécifiquement ERCC3 dans IP et IHC (fp). Il présente une réactivité envers Humain.

Aperçu rapide pour ERCC3 anticorps (AA 575-625) (ABIN7454400)

Antigène: ERCC3 (DNA Repair Protein Complementing XP-B Cells (ERCC3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERCC3 est non-conjugé

Application: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit anti-ERCC3 anticorps

Épitope: AA 575-625

Fonction: Rabbit anti-ERCC3 Antibody, Affinity Purified

Homologie: Mouse,Rat,Zebrafish,Bovine,Orangutan

Purification: Affinity Purified

Immunogène: between AA 575 and 625

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:2,000 to 1:10,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-ERCC3 antibody A301-337A.

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur ERCC3

Antigène: ERCC3 (DNA Repair Protein Complementing XP-B Cells (ERCC3))

Autre désignation: ERCC3

Sujet: Background: ERCC3 is a component of the core TFIIH basal transcription factor and functions as an ATP-dependent 3'-5' DNA helicase. ERCC3 is involved in nucleotide excision repair and is the cause of xeroderma pigmentosum complementation group B (XPB), also known as xeroderma pigmentosum II (XP2). Additionally, it has been found to be the cuase of Cockayne syndrome, and trichothiodystrophy (TTD). XPB is an autosomal recessive disease characterized by skin photosensitivity and a predisposition to skin cancer, and neurological abnormalities. Cockayne syndrome and TTD are similarly characterized by photosensitivity and neural abnormalities.

ID gène: 2071

NCBI Accession: NP_000113

UniProt: P19447

Pathways: Réparation de l'ADN