Presenilin 2 anticorps (AA 275-325)

N° du produit ABIN7455024

Cet anticorps Lapin Polyclonal détecte spécifiquement Presenilin 2 dans WB, IP et IHC (fp). Il présente une réactivité envers Humain.

Aperçu rapide pour Presenilin 2 anticorps (AA 275-325) (ABIN7455024)

Antigène: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Presenilin 2 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit anti-Presenilin 2 anticorps

Épitope: AA 275-325

Fonction: Rabbit anti-Presenilin-2 Antibody, Affinity Purified

Homologie: Mouse,Rat,Bovine,Pig,Orangutan

Purification: Affinity Purified

Immunogène: Between AA 275 and 325

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:1,000 - 1:5,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur Presenilin 2

Antigène: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Autre désignation: Presenilin-2

Sujet: Background: Presenilin-2 is a probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Presenilin-2 requires the other members of the gamma-secretase complex to have a protease activity. It may play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. It may function in the cytoplasmic partitioning of proteins [taken from the Universal Protein Resource (UniProt) P49810].

ID gène: 5664

NCBI Accession: NP_000438

UniProt: P49810

Pathways: Signalisation Notch, EGFR Signaling Pathway, Neurotrophin Signaling Pathway