ATM anticorps (AA 2577-3056)

N° du produit ABIN7539825

Cet anticorps Souris Monoclonal détecte spécifiquement ATM dans IHC et FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour ATM anticorps (AA 2577-3056) (ABIN7539825)

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ATM est non-conjugé

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 2A7A10

Détail du produit anti-ATM anticorps

Épitope: AA 2577-3056

Fonction: ATM Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human ATM (AA: 2577-3056) expressed in E. Coli.

Isotype: IgG2a

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur ATM

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Autre désignation: ATM

Sujet: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Poids moléculaire: 350.7kDa

ID gène: 472

UniProt: Q13315

Pathways: Signalisation p53, Apoptose, Réparation de l'ADN, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus