Insulin anticorps

N° du produit ABIN722601

Cet anticorps anti-Insulin est un anticorps Souris Monoclonal détectant Insulin dans IHC (p), IF (p) et IF (cc). Adapté pour Humain. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour Insulin anticorps (ABIN722601)

Antigène: Insulin (INS)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Insulin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Clone: 1G11

Détail du produit anti-Insulin anticorps

Réactivité croisée: Humain

Purification: Purified by Protein G.

Immunogène: Recombinant human Insulin protein

Isotype: IgG

Information d'application

Indications d'application: IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-Insulin (ABIN722601)

Zöllner, Jouni, Panzer, Khadour, Janzen, Wesche, Ten Berg, Schellong, Heinken, Greinacher, Bakchoul: "Platelet activation in the presence of neutral protamine Hagedorn insulin: a new feature of antibodies against protamine/heparin complexes." dans: Journal of thrombosis and haemostasis : JTH, (2016) (PubMed).

Détails sur Insulin

Antigène: Insulin (INS)

Autre désignation: Insulin

Sujet:

Synonyms: ILPR, INS, Insulin A chain, Insulin B chain, Insulin A chain, Insulin precursor, IRDN, Proinsulin, Proinsulin precursor, IDDM2, INS_HUMAN, MODY10.

Background: Insulin is a pancreatic hormone that regulates glucose and is involved in the synthesis of protein and fat. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Heterodimer of a B chain and an A chain linked by two disulfide bonds.Belongs to the insulin family. The insulin-link growth factors, IGF-I and IGF-II (also desinated somatomedin C and multiplication stimulating activator, respectvely), share approximatly 76 % sequence identity and are 50 % related to pro-insulin.IGF-I and IGF-II are nonglycosylated, single chain proteins of 70 and 76 amino acids in length, respectivelly. IGF-I functions as an autocrine regulator of growth in vaious, whereas the function of IGF-II is less well defined.

ID gène: 3630

Pathways: Signalisation NF-kappaB, Signalisation RTK, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation