IL-6 anticorps (AA 111-150)

N° du produit ABIN728083

Détail du produit anti-IL-6 anticorps

Antigène: IL-6 (IL6) (Interleukin 6 (IL6))

Épitope: AA 111-150

Reactivité: Humain, Souris, Rat, Lapin, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL-6 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Boeuf (Vache), Humain, Souris, Lapin, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from mouse IL-6

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-IL-6 (ABIN728083)

Brockmann, Corkhill, Jaroslawska, Dege, Brockmann, Kociok, Joussen: "Systemic Rho-kinase inhibition using fasudil in mice with oxygen-induced retinopathy." dans: Graefe's archive for clinical and experimental ophthalmology, Vol. 257, Issue 8, pp. 1699-1708, (2019) (PubMed).

Bai, Lv, Wang, Sun, Zhang: "LncRNA NEAT1 promotes inflammatory response and induces corneal neovascularization" dans: Journal of molecular endocrinology, Vol. 61, Issue 4, pp. 231-239, (2019) (PubMed).

Sun, Li, Jia, Wang, Li, Hu, Tian, Yang, Xing, Zhang, Wang, Xu, Wang, Zhang, Ren: "Neuroprotection by IFN-γ via astrocyte-secreted IL-6 in acute neuroinflammation." dans: Oncotarget, Vol. 8, Issue 25, pp. 40065-40078, (2018) (PubMed).

Haffner-Luntzer, Fischer, Prystaz, Liedert, Ignatius: "The inflammatory phase of fracture healing is influenced by oestrogen status in mice." dans: European journal of medical research, Vol. 22, Issue 1, pp. 23, (2017) (PubMed).

Prystaz, Kaiser, Kovtun, Haffner-Luntzer, Fischer, Rapp, Liedert, Strauss, Waetzig, Rose-John, Ignatius: "Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing." dans: The American journal of pathology, Vol. 188, Issue 2, pp. 474-490, (2017) (PubMed).

Taskin, Gungor, Adali, Yay, Onder, Inceboz: "A Humanized Anti-Interleukin 6 Receptor Monoclonal Antibody, Tocilizumab, for the Treatment of Endometriosis in a Rat Model." dans: Reproductive sciences (Thousand Oaks, Calif.), Vol. 23, Issue 5, pp. 662-9, (2016) (PubMed).

Kuracha, Thomas, Loggie, Govindarajan: "Patient-derived xenograft mouse models of pseudomyxoma peritonei recapitulate the human inflammatory tumor microenvironment." dans: Cancer medicine, Vol. 5, Issue 4, pp. 711-9, (2016) (PubMed).

Zhu, Wang, Yang, Wang, Li, Zhou, Zhang: "Hematopoietic Effects of Paeoniflorin and Albiflorin on Radiotherapy-Induced Myelosuppression Mice." dans: Evidence-based complementary and alternative medicine : eCAM, Vol. 2016, pp. 5789381, (2016) (PubMed).

Sun, Zeng, Cao, Song, Zhang, Liu: "Vibration Training Triggers Brown Adipocyte Relative Protein Expression in Rat White Adipose Tissue." dans: BioMed research international, Vol. 2015, pp. 919401, (2015) (PubMed).

Taskin, Topcu, Yay, Erken, Balcio?lu, Adali, Hismiogullar?: "Prevention of ovarian hyperstimulation syndrome in a rat model: comparison of the efficacy of tocilizumab with that of ranibizumab, cabergoline, and a gonadotropin-releasing hormone antagonist." dans: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, pp. 1-6, (2015) (PubMed).

Luo, Wang, Li, Wei, Zhang, Liu, Wang, Niu, Wang: "Maternal bisphenol a diet induces anxiety-like behavior in female juvenile with neuroimmune activation." dans: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 140, Issue 2, pp. 364-73, (2015) (PubMed).

Takayanagi, Crawford, Kobayashi, Obama, Tsuji, Elliott, Hashimoto, Rizzo, Eguchi: "Caveolin 1 is critical for abdominal aortic aneurysm formation induced by angiotensin II and inhibition of lysyl oxidase." dans: Clinical science (London, England : 1979), Vol. 126, Issue 11, pp. 785-94, (2014) (PubMed).

Détails sur IL-6

Antigène: IL-6 (IL6) (Interleukin 6 (IL6))

Autre désignation: IL-6 (IL6 Produits)

Synonymes: anticorps BSF2, anticorps HGF, anticorps HSF, anticorps IFNB2, anticorps IL-6, anticorps Il-6, anticorps ILg6, anticorps Ifnb2, anticorps il6, anticorps CHIL-6, anticorps interleukin 6, anticorps interleukin-6, anticorps IL6, anticorps Il6, anticorps il-6, anticorps IL-6

Sujet:

Synonyms: Il-6, Interleukin-6, B-cell hybridoma growth factor, Interleukin HP-1, Il6

Background: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.

ID gène: 16193

UniProt: P08505

Pathways: Signalisation TLR, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagy, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome