BBC3 anticorps (BCL2 Binding Component 3) (AA 120-170)

Details for Product anti-BBC3 Antibody No. ABIN731528
Antigène
  • BBC3
  • Puma
  • JFY-1
  • JFY1
  • PUMA
  • PUMA/JFY1
  • BCL2 binding component 3
  • Bcl-2 binding component 3
  • BBC3
  • Bbc3
  • bbc3
Épitope
AA 120-170
63
49
17
15
15
10
7
7
7
7
2
2
2
1
1
1
1
1
1
1
Reactivité
Humain, Souris, Rat (Rattus)
264
123
107
24
6
1
Hôte
Lapin
234
29
7
Clonalité
Polyclonal
Conjugué
Cet anticorp BBC3 est non-conjugé
10
9
8
7
7
6
4
4
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
233
80
68
39
34
22
21
13
12
6
3
2
2
1
1
Options
Immunogène KLH conjugated synthetic peptide derived from human PUMA
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others BBC3 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Puma (BBC3 Antibody Extrait)
Sujet

Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Isoform 3 fails to show any growth-inhibitory or apoptotic activity.

Subcellular location: Mitochondrion

Synonyms: JFY1, PUMA, JFY-1, Bcl-2-binding component 3, p53 up-regulated modulator of apoptosis, BBC3

ID gène 27113
UniProt Q96PG8
Pathways Signalisation p53, Positive Regulation of Endopeptidase Activity
Indications d'application WB 1:100-1000
FCM 1:20-100
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock -20 °C
Stockage commentaire Store at -20°C
Date de péremption 12 months
Images (Fournisseur)
Image no. 1 for anti-BCL2 Binding Component 3 (BBC3) (AA 120-170) antibody (ABIN731528) K562 lysates probed with PUMA Polyclonal Antibody, unconjugated at 1:300 overnight a...
Image no. 2 for anti-BCL2 Binding Component 3 (BBC3) (AA 120-170) antibody (ABIN731528) U87MG cells probed with Puma Polyclonal Antibody, Unconjugated at 1:50 for 30 minute...
Image no. 3 for anti-BCL2 Binding Component 3 (BBC3) (AA 120-170) antibody (ABIN731528) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti BBC3/PUMA Pol...
Produit citée dans: Su, Shi, Yan, Xi, Su: "Anticancer bioactive peptides suppress human colorectal tumor cell growth and induce apoptosis via modulating the PARP-p53-Mcl-1 signaling pathway." dans: Acta pharmacologica Sinica, Vol. 36, Issue 12, pp. 1514-9, 2016 (PubMed). Méthode utilisée: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Qiu, Cai, Gao, Gu, Liu: "A small peptide derived from p53 linker region can resume the apoptotic activity of p53 by sequestering iASPP with p53." dans: Cancer letters, Vol. 356, Issue 2 Pt B, pp. 910-7, 2014 (PubMed). Méthode utilisée: Immunoprecipitation (IP) (Échantillon (espèces): Human).

Zhang, Liu, Xia, Zhang, Zhang, Zhao, Chao, Jiang, Jiang: "Epithelial-mesenchymal transition is necessary for acquired resistance to cisplatin and increases the metastatic potential of nasopharyngeal carcinoma cells." dans: International journal of molecular medicine, Vol. 33, Issue 1, pp. 151-9, 2013 (PubMed). Méthode utilisée: Western Blotting (WB) (Échantillon (espèces): Human).

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