Recombinant Insulin anticorps (CF®405S)

N° du produit ABIN7655284

Cet anticorps Souris Monoclonal détecte spécifiquement Insulin dans IHC et IHC (fp). Il présente une réactivité envers Humain, Porc, Souris, Boeuf (Vache) et Lapin.

Aperçu rapide pour Recombinant Insulin anticorps (CF®405S) (ABIN7655284)

Antigène: Insulin (INS)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Porc, Souris, Boeuf (Vache), Lapin

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Insulin est conjugé à/à la CF®405S

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: RIRDN-805

Détail du produit anti-Insulin anticorps (CF®405S)

Fonction: Insulin / IRDN (beta-Cell & Insulinoma Marker) (rIRDN/805), CF405S conjugate

Attributs du produit: This antibody recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma markers.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogène: Recombinant full-length human Insulin protein

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Positive Control: MIA PaCa-2 cells. Pancreas.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from light

Stock: 4 °C

Stockage commentaire:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Date de péremption: 24 months

Détails sur Insulin

Antigène: Insulin (INS)

Autre désignation: Insulin

Sujet:

Synonyms: IDDM2, ILPR, IRDN, MODY10, Proinsulin

Gene Symbol: INS

Tissue Expression: Pancreatic beta cells

Poids moléculaire: 6 kDa

ID gène: 3630

UniProt: P01308

Pathways: Signalisation NF-kappaB, Signalisation RTK, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation