Recombinant RICTOR anticorps (C-Term)

N° du produit ABIN7795813

Cet anticorps anti-RICTOR Monoclonal Lapin (Clone BLR370N) (ABIN7795813) détecte spécifiquement RICTOR dans WB, IHC et IP. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant RICTOR anticorps (C-Term) (ABIN7795813)

Antigène: RICTOR (RPTOR Independent Companion of mTOR, Complex 2 (RICTOR))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp RICTOR est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: BLR370N

Détail du produit anti-RICTOR anticorps

Épitope: C-Term

Fonction: Rabbit anti-Rictor Recombinant Monoclonal Antibody [BLR370N]

Purification: Purified

Immunogène: between 1658 and 1708 (C-term)

Isotype: IgG

Information d'application

Indications d'application: IHC,1100 to 1500. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.,IP,20 μL/mg lysate,WB,11,000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 40 μg/mL

Buffer: Phosphate Buffered Saline (PBS) with 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: 2 - 8 °C

Date de péremption: 12 months

Détails sur RICTOR

Antigène: RICTOR (RPTOR Independent Companion of mTOR, Complex 2 (RICTOR))

Autre désignation: Rictor

Sujet: Rictor is a subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q6R327].

ID gène: 253260

UniProt: Q6R327

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, CXCR4-mediated Signaling Events