PDGFB anticorps (AA 27-158)

N° du produit ABIN7863222

Cet anticorps anti-PDGFB Monoclonal Souris (Clone PDGFB-3071) (ABIN7863222) détecte spécifiquement PDGFB dans IHC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour PDGFB anticorps (AA 27-158) (ABIN7863222)

Antigène: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PDGFB est non-conjugé

Application: Immunohistochemistry (IHC)

Clone: PDGFB-3071

Détail du produit anti-PDGFB anticorps

Épitope: AA 27-158

Fonction: PDGF beta (PDGFB) Antibody

Specificité: PDGF is a mitogen for mesenchyme- and glia-derived cells. It consists of two disulfide-bonded polypeptide chains, A and B, and occurs as three isoforms, PDGF AA, AB and BB. The three isoforms bind, with different affinities, to two receptor types, °™and æ, which are structurally related and endowed with protein-tyrosine kinase domains. Ligand binding induces activation of the receptor kinases by formation of receptor dimers, the A subunit of PDGF binds only to °™ receptors with high affinity, whereas the B subunit can bind to both °™ and æ receptors. Evidence suggests that PDGF may function as a neurotrophic factor. Receptors for PDGF-A are expressed in oligodendrocyte progenitor cells whereas receptors for PDGF-B are expressed on neurons. These facts suggest that the different isoforms of PDGF may regulate growth and differentiation of different cell types in the developing central nervous system through paracrine and autocrine routes.

Purification: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G.

Immunogène: Recombinant fragment of human PDGFB protein (around aa 27-158) (exact sequence is proprietary)

Isotype: IgG2c, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Date de péremption: 24 months

Détails sur PDGFB

Antigène: PDGFB (Platelet Derived Growth Factor Subunit B (PDGFB))

Autre désignation: PDGF beta

Sujet:

Becaplermin, c sis, Oncogene SIS, PDGF Beta chain, PDGF2, Platelet derived growth factor 2, Platelet derived growth factor B chain, Platelet derived growth factor beta, Platelet derived growth factor beta polypeptide (oncogene SIS), Platelet derived growth factor beta polypeptide (simian sarcoma viral (v sis) oncogene homolog)

Human colon, kidney or lymph node.

Poids moléculaire: 14kDa (monomeric B chain), 31-35kDa (dimer)

ID gène: 5155, 1976

UniProt: P01127

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling