BCL10 anticorps (AA 122-168)

N° du produit ABIN7870331

Cet anticorps Souris Monoclonal détecte spécifiquement BCL10 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour BCL10 anticorps (AA 122-168) (ABIN7870331)

Antigène: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp BCL10 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SPM520

Détail du produit anti-BCL10 anticorps

Épitope: AA 122-168

Fonction: Bcl10 Antibody

Purification: Protein G affinity chromatography

Immunogène: Amino acids 122-168 were used as the immunogen for this Bcl10 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: The optimal dilution of the Bcl10 antibody for each application should be determined by the researcher.

1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10 mM Tris with 1 mM EDTA for 10-20 min followed by cooling at RT for 20 minutes.
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Bcl10 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur BCL10

Antigène: BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

Autre désignation: Bcl10

Sujet: Bcl10, with an N-terminal caspase recruitment domain (CARD), is found in a number of apoptotic regulatory molecules. It was identified through its direct involvement in t(1,14) of mucosa-associated lymphoid tissue (MALT) lymphoma. Expression of Bcl10 was shown to induce NF-kB activation in a NIK-dependent pathway. This mAb labels subpopulations of normal B and T cells and is a useful tool for the sub-classification of lymphomas. In MALT lymphomas with the t(1,14) translocation, while 55 % of MALT lymphomas lacking this translocation exhibited the same labeling pattern, although at a much lower level.

UniProt: O95999

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins