ATM anticorps (AA 1900-2500)

N° du produit ABIN7871651

Cet anticorps Souris Monoclonal détecte spécifiquement ATM dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour ATM anticorps (AA 1900-2500) (ABIN7871651)

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ATM est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: ATM-9472

Détail du produit anti-ATM anticorps

Épitope: AA 1900-2500

Fonction: ATM Antibody / Ataxia telangiectasia mutated

Purification: Protein A affinity

Immunogène: A portion of amino acids 1900-2500 from human ATM protein was used as the immunogen for the ATM antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the ATM antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the ATM antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur ATM

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Autre désignation: ATM

Sujet: The phosphatidylinositol kinase (PIK) family members fall into two distinct subgroups. The first subgroup contains proteins such as the PI 3- and PI 4-kinases and the second group comprises the PIK-related kinases. The PIK-related kinases include Atm, DNA-PKCS and FRAP. These proteins have in common a region of homology at their carboxy-termini that is not present in the PI 3- and PI 4-kinases. The Atm gene is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) that is characterized by cerebellar degeneration (ataxia) and the appearance of dilated blood vessels (telangiec-tases) in the conjunctivae of the eyes. AT cells are hypersensitive to ionizing radiation, impaired in mediating the inhibition of DNA synthesis and display delays in p53 induction.

UniProt: Q13315

Pathways: Signalisation p53, Apoptose, Réparation de l'ADN, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus