MCM6 anticorps (AA 228-368)

N° du produit ABIN7872423

L’anticorps anti-MCM6 Monoclonal Souris est utilisé pour la détection de MCM6 dans des échantillons de Humain. Il a été validé pour WB et IHC (p).

Aperçu rapide pour MCM6 anticorps (AA 228-368) (ABIN7872423)

Antigène: MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MCM6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MCM6-2999

Détail du produit anti-MCM6 anticorps

Épitope: AA 228-368

Fonction: MCM6 Antibody

Purification: Protein G affinity chromatography

Immunogène: A recombinant human partial protein (amino acids 228-368) was used as the immunogen for this MCM6 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the MCM6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the MCM6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur MCM6

Antigène: MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))

Autre désignation: MCM6

Sujet: The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM6 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1/S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the post-replicative state of the cell. MCM2/MCM6 complexes function as substrates for Cdc2/cyclin B in vitro.

UniProt: Q14566

Pathways: Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA