SHP1 anticorps (full length)

N° du produit ABIN7878905

Cet anticorps Souris Monoclonal détecte spécifiquement SHP1 dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour SHP1 anticorps (full length) (ABIN7878905)

Antigène: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SHP1 est non-conjugé

Application: Western Blotting (WB)

Clone: CPTC-PTPN6-2

Détail du produit anti-SHP1 anticorps

Épitope: full length

Fonction: PTPN6 Antibody / SHP-1

Purification: Protein G affinity chromatography

Immunogène: Recombinant human full-length PTPN6 protein was used as the immunogen for the PTPN6 antibody.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal dilution of the PTPN6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the PTPN6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur SHP1

Antigène: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Autre désignation: PTPN6

Sujet: PTPN6, which is also designated as SHP-1, is expressed primarily in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. It maps to 12p13, a region commonly involved in leukemia-associated chromosomal abnormalities. SHP-1 plays a role in modulating intracellular signaling for various molecules. In T-cell lymphomas and other malignancies, SHP-1 phosphatase expression is lost, by a thus far undetermined mechanism. Preliminary studies suggest that it may be helpful in differentiating mantle/marginal zone lymphomas (SHP-1+) from follicular lymphomas (SHP-1 negative).

UniProt: P29350

Pathways: Signalistation JAK/STAT, TCR Signaling, Signalisation TLR, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling