Recombinant p53 anticorps (full length)
Aperçu rapide pour Recombinant p53 anticorps (full length) (ABIN7879246)
Antigène
Voir toutes p53 (TP53) AnticorpsType d'anticorp
Reactivité
Hôte
Clonalité
Conjugué
Application
Classe de qualité
Clone
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Épitope
- full length
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Fonction
- Recombinant Tumor Protein 53 Antibody / p53 (azide and preservative free)
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Purification
- Protein A affinity
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Immunogène
- A recombinant human full-length TP53 protein was used as the immunogen for the recombinant Tumor Protein 53 antibody.
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Isotype
- IgG, kappa
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Indications d'application
- Optimal dilution of the recombinant Tumor Protein 53 antibody should be determined by the researcher.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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Agent conservateur
- Azide free
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Stock
- -20 °C
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Stockage commentaire
- Aliquot the recombinant Tumor Protein 53 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- p53 (TP53) (Tumor Protein P53 (TP53))
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Autre désignation
- Tumor Protein 53
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Sujet
- P53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
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UniProt
- P04637
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Pathways
- Signalisation p53, Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, L'effet Warburg
Antigène
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