ATM anticorps (AA 2870-3056) (Fluoro488)

N° du produit ABIN7970493

Cet anticorps Lapin Polyclonal détecte spécifiquement ATM dans FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour ATM anticorps (AA 2870-3056) (Fluoro488) (ABIN7970493)

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATM est conjugé à/à la Fluoro488

Application: Flow Cytometry (FACS)

Détail du produit anti-ATM anticorps (Fluoro488)

Épitope: AA 2870-3056

Fonction: Anti-Serine-protein kinase ATM ATM Antibody Fluoro488 Conjugated

Specificité: No cross reactivity with other proteins.

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human ATM shares 95% amino acid (aa) sequence identity with mouse ATM.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human ATM recombinant protein (Position: D2870-V3056). Human ATM shares 95% amino acid (aa) sequence identity with mouse ATM.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur ATM

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Autre désignation: ATM

Sujet:

Background: ATM (ataxia telangiectasia mutated), also known as TEL1 or TELO1, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks. The ATM protein is a member of the phosphatidylinositol 3-kinase family of proteins that respond to DNA damage by phosphorylating key substrates involved in DNA repair and/or cell cycle control. The ATM gene is mapped to chromosome 11q22.3. ATM has an essential role in the reconstitutive capacity of hematopoietic stem cells but is not as important for the proliferation or differentiation of progenitors in a telomere-independent manner. ATM functions ly in the repair of chromosomal DNA double-stranded breaks by maintaining DNA ends in repair complexes generated during lymphocyte gene assembly.

Gene Full Name: ATM serine/threonine kinase

Sequence Similarities: Belongs to the PI3/PI4-kinase family. ATM subfamily.

ID gène: 472

UniProt: Q13315

Pathways: Signalisation p53, Apoptose, Réparation de l'ADN, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus