GTPase NRas anticorps (C-Term) (FITC)

N° du produit ABIN7995597

Cet anticorps Lapin Polyclonal détecte spécifiquement GTPase NRas dans FACS. Il présente une réactivité avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour GTPase NRas anticorps (C-Term) (FITC) (ABIN7995597)

Antigène: GTPase NRas (NRAS)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GTPase NRas est conjugé à/à la FITC

Application: Flow Cytometry (FACS)

Détail du produit anti-GTPase NRas anticorps (FITC)

Épitope: C-Term

Fonction: Anti-NRAS Antibody FITC Conjugated

Réactivité croisée (Details): No cross-reactivity with other proteins

Homologie: Human NRAS shares 100% amino acid (aa) sequence identity with both mouse,rat NRAS.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the C-terminus of human NRAS. Human NRAS shares 100% amino acid (aa) sequence identity with both mouse and rat NRAS.

Isotype: IgG

Information d'application

Indications d'application: Flow Cytometry, Optimal dilutions should be determined by end users.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Each vial contains 50 % glycerol, 0.9 % NaCl, 0.2 % Na2HPO4, 0.02 % Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: At -20°C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

Date de péremption: 12 months

Détails sur GTPase NRas

Antigène: GTPase NRas (NRAS)

Autre désignation: NRAS

Sujet:

Background: This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.

Gene Full Name: NRAS proto-oncogene, GTPase

ID gène: 4893

UniProt: P01111

Pathways: Signalisation p53, Signalisation MAPK, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling