p53 anticorps

N° du produit ABIN866051

L’anticorps anti-p53 Polyclonal produit chez le Lapin a été validé pour WB. Il convient pour la détection de p53 dans des échantillons provenant de Humain. }

Aperçu rapide pour p53 anticorps (ABIN866051)

Antigène: p53 (TP53) (Tumor Protein P53 (TP53))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp p53 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-p53 anticorps

Specificité: This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of N-terminal residues of p53.

Réactivité croisée: Humain, Souris

Attributs du produit: Positive Control: A431. Cellular Localization: Cytoplasm, nucleus

Purification: Immunogen affinity purified

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1,000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5mg/ml

Buffer: 1xTBS (pH7.4), 0.5% BSA, 25% Glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Détails sur p53

Antigène: p53 (TP53) (Tumor Protein P53 (TP53))

Autre désignation: p53

Sujet: P53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. It acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. P53 is involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. p53 is frequently mutated or inactivated in about 60% of cancers

Poids moléculaire: ~70kDa

UniProt: Q91XH8

Pathways: Signalisation p53, Signalisation MAPK, Signalisation PI3K-Akt, Apoptose, AMPK Signaling, Chromatin Binding, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Autophagy, L'effet Warburg