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CD22 anticorps (AA 839-843)

CD22 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated

N° du produit ABIN871517

Fiche de données

Antigène Voir toutes CD22 Anticorps

CD22 (CD22 Molecule (CD22))
Épitope
16

11

6

5

4

3

3

3

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 839-843
Reactivité
154

50

24

5

3

2

2

1
Humain
Hôte
101

62

14
Lapin
Anticorps secondaires appropriés
Clonalité
125

54
Polyclonal
Conjugué
82

15

12

11

8

5

4

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
Cet anticorp CD22 est non-conjugé
Application
112

71

46

39

38

19

13

11

11

8

5

4

3

3

3

2

1

1

1

1

1

1

1

1

1
Western Blotting (WB)

Specificité

The antibody detects endogenous level of total CD22 protein.

Purification

Affinity purified

Immunogène

Peptide sequence around AA 839-843 (N-V-D-Y-V) derived from Human CD22. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

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CD22 Reactivité: Humain IHC Hôte: Lapin Monoclonal MSVA-022R unconjugated Recombinant Antibody

Indications d'application

Western blotting: 1:500-1:1000

Restrictions

For Research Use only
Format

Liquid

Concentration

1 mg/mL

Buffer

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock

4 °C/-20 °C

Stockage commentaire

Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Antigène

CD22 (CD22 Molecule (CD22))

Autre désignation

CD22 (CD22 Produits)

Synonymes

anticorps A530093D23, anticorps Lyb-8, anticorps Lyb8, anticorps SIGLEC-2, anticorps SIGLEC2, anticorps siglec-2, anticorps CD22 antigen, anticorps CD22 molecule, anticorps Cd22, anticorps CD22

Sujet

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins, one of which is CD45. Preferentially binds to a-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Poids moléculaire

140 kDa

ID gène

933

NCBI Accession

NP_001762

UniProt

P20273