DDX58 anticorps (pThr170) (Alexa Fluor 488)

N° du produit ABIN877555

Détail du produit anti-DDX58 anticorps (Alexa Fluor 488)

Antigène: DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

Épitope: pThr170

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDX58 est conjugé à/à la Alexa Fluor 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Souris

Homologie: Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human DDX58 around the phosphorylation site of Thr170

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur DDX58

Antigène: DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

Autre désignation: DDX58 (DDX58 Produits)

Synonymes: anticorps RIG-I, anticorps RIGI, anticorps RLR-1, anticorps 6430573D20Rik, anticorps C330021E21, anticorps RHIV-1, anticorps RIG-1, anticorps DExD/H-box helicase 58, anticorps DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, anticorps DEXD/H-box helicase 58, anticorps DDX58, anticorps Ddx58

Sujet:

Synonyms: DEAD/H Asp-Glu-Ala-Asp/His box polypeptide RIG-I, DKFZp434J1111, DKFZp686N19181, FLJ13599, C330021E21, OTTHUMP00000045225, DEAD Asp-Glu-Ala-Asp box polypeptide 58, DEAD Asp Glu Ala Asp/His box polypeptide, DEAD box protein 58, Probable ATP dependent RNA helicase DDX58, Retinoic acid inducible gene 1 protein, RIG I, rig-I, RIG1, rigi, RNA helicase.

Background: The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG1/DDX58) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG1/DDX58 activates the kinases TBK1 and IKKe through the adaptor protein IPS1. These kinases then phosphorylate the transcription factors IRF3 and IRF7 which are essential for the expression of type-I interferons. RIG1/DDX58 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.

ID gène: 23586

Pathways: Activation of Innate immune Response, Hepatitis C