DDR1 anticorps (pTyr513) (Alexa Fluor 350)

N° du produit ABIN879801

Détail du produit anti-DDR1 anticorps (Alexa Fluor 350)

Antigène: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Épitope: pTyr513

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DDR1 est conjugé à/à la Alexa Fluor 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain

Homologie: Mouse,Rat,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic phosphopeptide derived from human MCK10 around the phosphorylation site of Tyr513

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur DDR1

Antigène: DDR1 (Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))

Autre désignation: MCK10 (DDR1 Produits)

Synonymes: anticorps CG11573, anticorps CG13984, anticorps CG13985, anticorps CG33531, anticorps CG9488, anticorps CG9490, anticorps CT33540, anticorps DDR, anticorps Dmel\\CG33531, anticorps Dmel_CG13984, anticorps 6030432F18, anticorps AI323681, anticorps CD167a, anticorps Cak, anticorps Nep, anticorps PTK3A, anticorps CAK, anticorps CD167, anticorps EDDR1, anticorps HGK2, anticorps MCK10, anticorps NEP, anticorps NTRK4, anticorps PTK3, anticorps RTK6, anticorps TRKE, anticorps Drd1, anticorps PTK3D, anticorps Discoidin domain receptor, anticorps discoidin domain receptor family, member 1, anticorps discoidin domain receptor tyrosine kinase 1, anticorps Ddr, anticorps Ddr1, anticorps DDR1

Sujet:

Synonyms: MCK10 phospho Y513, p-MCK10 phospho Y513, CAK, CD167a, DDR1CD 167, CD167, Cell adhesion kinase, DDR 1, DDR, DDR1, Discoidin domain receptor, Discoidin receptor tyrosine kinase isoform a, EDDR 1, Epithelial discoidin domain receptor 1, Epithelial specic receptor kinase, Mammarian carcinoma kinase 10, Neuroepithelial tyrosine kinase, Neurotrophic tyrosine kinase receptor type 4, NTRK 4, PTK 3, PTK 3A protein tyrosine kinase 3A, Receptor tyrosine kinase NEP, RTK 6, TRK E, Tyrosine kinase receptor E, DDR1_HUMAN.

Background: Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.

ID gène: 780

UniProt: Q08345

Pathways: Signalisation RTK, Smooth Muscle Cell Migration