DTNBP1 anticorps (AA 101-200) (Alexa Fluor 350)

N° du produit ABIN894517

Détail du produit anti-DTNBP1 anticorps (Alexa Fluor 350)

Antigène: DTNBP1 (Dystrobrevin Binding Protein 1 (DTNBP1))

Épitope: AA 101-200

Reactivité: Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DTNBP1 est conjugé à/à la Alexa Fluor 350

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Rat

Homologie: Human,Mouse,Cow,Sheep,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human DTNBP1

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur DTNBP1

Antigène: DTNBP1 (Dystrobrevin Binding Protein 1 (DTNBP1))

Autre désignation: Dtnbp1 (DTNBP1 Produits)

Synonymes: anticorps 5430437B18Rik, anticorps AW048963, anticorps Bloc1s8, anticorps dysbindin, anticorps sdy, anticorps BLOC1S8, anticorps DBND, anticorps HPS7, anticorps My031, anticorps SDY, anticorps dtnbp1, anticorps zgc:56462, anticorps MGC83903, anticorps dbnd, anticorps hps7, anticorps my031, anticorps MGC85477, anticorps DTNBP1, anticorps CG6856, anticorps Ddysb, anticorps Dmel\\CG6856, anticorps si:ch211-285p6.1, anticorps dystrobrevin binding protein 1, anticorps Dysbindin, anticorps dystrobrevin binding protein 1a, anticorps dystrobrevin binding protein 1 L homeolog, anticorps dystrobrevin binding protein 1 S homeolog, anticorps dystrobrevin binding protein 1b, anticorps Dtnbp1, anticorps DTNBP1, anticorps dtbp1, anticorps dtnbp1a, anticorps dtnbp1.L, anticorps dtnbp1.S, anticorps dtnbp1, anticorps Dysb, anticorps dtnbp1b

Sujet:

Synonyms: SDY, DBND, HPS7, My031, BLOC1S8, Dysbindin, Biogenesis of lysosome-related organelles complex 1 subunit 8, BLOC-1 subunit 8, Dysbindin-1, Dystrobrevin-binding protein 1, Hermansky-Pudlak syndrome 7 protein, HPS7 protein, DTNBP1

Background: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.

ID gène: 84062

UniProt: Q96EV8

Pathways: Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling