GZMA anticorps (Granzyme A (Granzyme 1, Cytotoxic T-Lymphocyte-Associated serine Esterase 3)) (Alexa Fluor 647)

Details for Product anti-GZMA Antibody No. ABIN900004, Fournisseur: Connectez-vous pour afficher
Antigène
  • gzmA
  • GZMA
  • AW494114
  • Ctla-3
  • Ctla3
  • Hf
  • SE1
  • TSP-1
  • TSP1
  • CTLA3
  • HFSP
  • granzyme A
  • Granzyme A
  • granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
  • gzmA
  • GZMA
  • graa
  • Gzma
Reactivité
Humain, Souris, Rat (Rattus)
110
39
24
3
2
1
1
1
1
1
Hôte
Lapin
68
43
13
1
Clonalité
Polyclonal
Conjugué
Cet anticorp GZMA est conjugé à/à la Alexa Fluor 647
7
5
5
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
59
41
35
25
20
12
10
8
6
4
3
2
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène KLH conjugated synthetic peptide derived from human Granzyme A
Isotype IgG
Purification Purified by Protein A.
Plasmids, Primers & others Plasmids, Primers & others GZMA products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation Granzyme A (GZMA Antibody Extrait)
Sujet

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent cell death with morphological features of apoptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.

Subcellular location: Nucleus

Synonyms: HFSP, CTLA3, Granzyme A, CTL tryptase, Cytotoxic T-lymphocyte proteinase 1, Fragmentin-1, Granzyme-1, Hanukkah factor, H factor, HF, GZMA

ID gène 3001
UniProt P12544
Pathways Apoptose
Indications d'application IF(IHC-P) 1:50-200
Restrictions For Research Use only
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Stock 4 °C
Stockage commentaire Store at 4°C
Date de péremption 12 months
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