PDIA2 anticorps (AA 431-525) (Alexa Fluor 350)

N° du produit ABIN910576

Détail du produit anti-PDIA2 anticorps (Alexa Fluor 350)

Antigène: PDIA2 (Protein Disulfide Isomerase Family A, Member 2 (PDIA2))

Épitope: AA 431-525

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDIA2 est conjugé à/à la Alexa Fluor 350

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Souris, Rat

Homologie: Human

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human PDIA2

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur PDIA2

Antigène: PDIA2 (Protein Disulfide Isomerase Family A, Member 2 (PDIA2))

Autre désignation: PDIA2 (PDIA2 Produits)

Synonymes: anticorps PDIA2, anticorps DKFZp468D2220, anticorps 1810041F13Rik, anticorps AI661267, anticorps Pdip, anticorps Pdipl, anticorps PDA2, anticorps PDI, anticorps PDIP, anticorps PDIR, anticorps protein disulfide isomerase family A member 2, anticorps protein disulfide isomerase associated 2, anticorps protein disulfide isomerase family A, member 2, anticorps PDIA2, anticorps Pdia2

Sujet:

Synonyms: Pancreatic protein disulfide isomerase, PDA2, PDI, PDIA2, PDIP, Protein disulfide isomerase A2, Protein disulfide isomerase, Protein disulfide isomerase family A member 2, PDIA2_HUMAN.

Background: The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.

ID gène: 64714

Pathways: Maintenance of Protein Location, Cell RedoxHomeostasis, Unfolded Protein Response