NEDD4 anticorps (AA 801-900) (Biotin)

N° du produit ABIN916374

Détail du produit anti-NEDD4 anticorps (Biotin)

Antigène: NEDD4 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4))

Épitope: AA 801-900

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NEDD4 est conjugé à/à la Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Rat

Homologie: Mouse,Dog,Cow,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human NEDD4

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur NEDD4

Antigène: NEDD4 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4))

Autre désignation: NEDD4 (NEDD4 Produits)

Synonymes: anticorps NEDD4-1, anticorps RPF1, anticorps AA959633, anticorps AL023035, anticorps AU019897, anticorps E430025J12Rik, anticorps Nedd4-1, anticorps Nedd4a, anticorps mKIAA0093, anticorps CG32184, anticorps CG42279, anticorps CG7555, anticorps DNedd4, anticorps Dmel\\CG42279, anticorps Dmel_CG32184, anticorps Dmel_CG7555, anticorps dNedd4, anticorps dNedd4-1, anticorps nedd4, anticorps GB16853, anticorps NEDD4, anticorps Nedd4, anticorps neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase, anticorps neural precursor cell expressed, developmentally down-regulated 4, anticorps CG42279 gene product from transcript CG42279-RJ, anticorps E3 ubiquitin-protein ligase Nedd-4, anticorps E3 ubiquitin-protein ligase NEDD4, anticorps NEDD4, anticorps Nedd4, anticorps LOC411723, anticorps LOC100457150, anticorps nedd4, anticorps LOC100547485

Sujet:

Synonyms: RPF1, NEDD4-1, E3 ubiquitin-protein ligase NEDD4, Cell proliferation-inducing gene 53 protein, Neural precursor cell expressed developmentally down-regulated protein 4, NEDD-4, NEDD4, KIAA0093, PIG53

Background: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Promotes ubiquitination of RAPGEF2. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2. Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding.

ID gène: 4734

UniProt: P46934

Pathways: Signalisation Notch, Intracellular Steroid Hormone Receptor Signaling Pathway, Skeletal Muscle Fiber Development, Signaling Events mediated by VEGFR1 and VEGFR2