HVEM anticorps (AA 51-150) (Alexa Fluor 488)

N° du produit ABIN918128

Détail du produit anti-HVEM anticorps (Alexa Fluor 488)

Antigène: HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))

Épitope: AA 51-150

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HVEM est conjugé à/à la Alexa Fluor 488

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain

Homologie: Dog,Horse

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human TNFRSF14

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur HVEM

Antigène: HVEM (TNFRSF14) (Tumor Necrosis Factor Receptor Superfamily, Member 14 (TNFRSF14))

Autre désignation: Tnfrsf14/Hvem (TNFRSF14 Produits)

Synonymes: anticorps ATAR, anticorps CD270, anticorps HVEA, anticorps HVEM, anticorps LIGHTR, anticorps TR2, anticorps Atar, anticorps HveA, anticorps Hvem, anticorps Tnfrs14, anticorps TNF receptor superfamily member 14, anticorps tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator), anticorps Tnfrsf14, anticorps TNFRSF14

Classe de substances: Viral Protein

Sujet:

Synonyms: Tumor necrosis factor receptor superfamily member 14, HVEML, ATAR, CD258, CD258 antigen, CD40 like protein precursor, Herpesvirus entry mediator A, Herpesvirus entry mediator, Herpesvirus entry mediator ligand, HVEA, HVEM, HVEM L, HVEML, LIGHT, LIGHTR, TNFSF 14, TR2, Tumor necrosis factor receptor like gene2, TNR14_HUMAN.

Background: TNFRSF14 is a type I membrane protein belonging to the TNF receptor superfamily. This receptor mediates herpes virus entry into cells during infection. TNFRSF14 is able to inhibit the proliferation, activation, and cytokine production of T cells. It has an extracellular domain containing several cysteine-rich repeats and a short cytoplasmic region containing a TRAF (TNF receptor-associated factor) interaction domain. The extracellular domain of TNFRSF14 interacts with the herpes simplex virus envelope glycoprotein D. TNFRSF14 binds two cellular ligands: lymphotoxin alpha and LIGHT. LIGHT is a transmembrane protein expressed and shed from the surface of activated T cells, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes. The LIGHT:TNFRSF14 interaction controls immune response functions by cell death induction as well as cell activation. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells.

ID gène: 8764

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints