TLR6 anticorps (Internal Region)

N° du produit ABIN920626

Détail du produit anti-TLR6 anticorps

Antigène: TLR6 (Toll-Like Receptor 6 (TLR6))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TLR6 est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: Positive Control: Located in the membrane, TLR6 is detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells.

Purification: Antigen Immunoaffinity purified

Immunogène: Rabbit polyclonal TLR6 antibody was raised against a peptide corresponding to 13 amino acids near the center of TLR6.

Isotype: IgG

Information d'application

Indications d'application: Western blot: use at 0.5-1 µg/mL

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline with 0.02% sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur TLR6

Antigène: TLR6 (Toll-Like Receptor 6 (TLR6))

Abstract: TLR6 Produits

Synonymes: anticorps TLR1, anticorps TLR16, anticorps CD286, anticorps TLR-6, anticorps toll-like receptor 1 family member A, anticorps toll like receptor 6, anticorps toll-like receptor 6, anticorps TLR1A, anticorps TLR6, anticorps Tlr6

Sujet: Toll-like receptors (TRLs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR6 was first identified as a close homolog of TLR1, sharing 69% sequence identity. Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 heterodimers coordinate macrophage activation by Gram-positive bacteria and the yeast cell wall particle zymosan. Activation of these complexes not only initiates pro-inflammatory cascades, but can also lead to apoptotic responses. Synonyms:

Poids moléculaire: 96 kDa

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades