TIRAP anticorps (Internal Region)

N° du produit ABIN920633

Détail du produit anti-TIRAP anticorps

Antigène: TIRAP (Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TIRAP est non-conjugé

Application: Western Blotting (WB)

Attributs du produit: Positive Control: Found in the cytoplasm and highly expressed in the liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon, and brain.

Purification: Antigen Immunoaffinity purified

Immunogène: Rabbit polyclonal TIRAP antibody was raised against a peptide corresponding to amino acids near the middle of human TIRAP.

Isotype: IgG

Information d'application

Indications d'application: Western blot: use at 4 µg/mL

Restrictions: For Research Use only

Stockage

Buffer: Phosphate buffered saline with 0.02% sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur TIRAP

Antigène: TIRAP (Toll-Interleukin 1 Receptor (TIR) Domain Containing Adaptor Protein (TIRAP))

Autre désignation: Toll Interleukin 1 Receptor Adaptor Protein (TIRAP) (TIRAP Produits)

Synonymes: anticorps mal, anticorps wyatt, anticorps BACTS1, anticorps Mal, anticorps MyD88-2, anticorps AA407980, anticorps C130027E04Rik, anticorps Tlr4ap, anticorps Wyatt, anticorps toll-interleukin 1 receptor (TIR) domain containing adaptor protein, anticorps TIR domain containing adaptor protein, anticorps toll-interleukin 1 receptor (TIR) domain containing adaptor protein L homeolog, anticorps toll-interleukin 1 receptor (TIR) domain-containing adaptor protein, anticorps tirap, anticorps TIRAP, anticorps tirap.L, anticorps Tirap

Sujet: Toll-like receptors (TRLs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. In TIRAP deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-B and MAP kinase activation, suggesting that TIRAP is also involved in TLR4 signaling. Synonyms:

Poids moléculaire: 26 kDa

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades