PSMD10 anticorps (N-Term)

N° du produit ABIN928857

Détail du produit anti-PSMD10 anticorps

Antigène: PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PSMD10 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Souris

Purification: Purified

Immunogène: Psmd10 antibody was raised in rabbit using the N terminal of Psmd10 as the immunogen

Information d'application

Indications d'application: Optimal conditions should be determined by the investigator.

Commentaires:

Psmd10 Blocking Peptide, catalog no. 33R-4354, is also available for use as a blocking control in assays to test for specificity of this Psmd10 antibody

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Détails sur PSMD10

Antigène: PSMD10 (Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 (PSMD10))

Autre désignation: Psmd10 (PSMD10 Produits)

Synonymes: anticorps gankyrin, anticorps zgc:109707, anticorps dJ889N15.2, anticorps p28, anticorps p28(GANK), anticorps AW554874, anticorps p28Gank, anticorps proteasome 26S subunit, non-ATPase 10, anticorps proteasome (prosome, macropain) 26S subunit, non-ATPase, 10, anticorps psmd10, anticorps PSMD10, anticorps Psmd10

Sujet: Psmd10 acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly,Psmd10 is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module By similarity.Psmd10 acts as an oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression of this gene is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Psmd10 regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Synonyms: Polyclonal Psmd10 antibody, Anti-Psmd10 antibody, proteasome, prosome, macropain 26S subunit, non-ATPase, 10 antibody, AW554874 antibody.

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Ubiquitin Proteasome Pathway