Calcineurin B anticorps

N° du produit ABIN933160

Détail du produit anti-Calcineurin B anticorps

Antigène: Calcineurin B (CAN)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Calcineurin B est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain, Souris, Rat (Rattus)

Stérilité: Filtered

Immunogène: Calcineurin B antibody was raised in mouse using E. coli-derived recombinant human calcineurin B as the immunogen.

Clone: 323417

Isotype: IgG2a

Information d'application

Indications d'application: WB: 0.5 µg/mL
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Reconstitute with sterile PBS.

Concentration: Lot specific

Buffer: Lyophilized from a 0.2 µm filtered solution in PBS with 5 % trehalose.

Conseil sur la manipulation: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.

Détails sur Calcineurin B

Antigène: Calcineurin B (CAN)

Autre désignation: Calcineurin B (CAN Produits)

Synonymes: anticorps PPP3RL, anticorps BcDNA:RH11383, anticorps CG4209, anticorps CNB, anticorps Can, anticorps CnB, anticorps Dmel\\CG4209, anticorps canB-4F, anticorps dCnB1, anticorps Cnb, anticorps Cblp, anticorps CaNB2, anticorps protein phosphatase 3 regulatory subunit B, beta, anticorps Calcineurin B, anticorps calcineurin B, anticorps protein phosphatase 3, regulatory subunit B, beta, anticorps protein phosphatase 3 regulatory subunit B, alpha, anticorps protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II), anticorps PPP3R2, anticorps CanB, anticorps Cnb, anticorps Ppp3r2, anticorps PPP3R1

Sujet: Calcineurin (CN) is a protein phosphatase also known as protein phosphatase 3, PPP3CA, and formerly known as protein phosphatase 2B (PP2B). It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates NFATc (Nuclear Factor of Activated T cell, cytoplasmic), a transcription factor, by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of T cell response. Calcineurin is the target of a class of drugs called calcineurin inhibitors, which includes ciclosporin, pimecrolimus and tacrolimus. Synonyms: Monoclonal Calcineurin B antibody, Anti-Calcineurin B antibody.

Pathways: Cellular Glucan Metabolic Process, VEGF Signaling