Insulin anticorps

N° du produit ABIN94408

Détail du produit anti-Insulin anticorps

Antigène: Insulin (INS)

Reactivité: Humain, Porc, Boeuf (Vache)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Insulin est non-conjugé

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Radioimmunoassay (RIA)

Specificité: The antibody IN-05 reacts with insulin, one of the major regulatory endocrine hormones of intermediate metabolism, normally secreted by the beta cells (a type of islet cells) of the pancreas, it is also present in tumors of B cell origin such as insulinoma.

Réactivité croisée (Details): Human, Bovine, Porcine

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Porcine insulin.

Clone: IN-05

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-Insulin (ABIN94408)

Meesaragandla, Karanth, Janke, Delcea: "Biopolymer-coated gold nanoparticles inhibit human insulin amyloid fibrillation." dans: Scientific reports, Vol. 10, Issue 1, pp. 7862, (2020) (PubMed).

Horejsí, Hilgert, Kristofová, Satayalai: "Murine hybridoma monoclonal antibodies against insulin: cross-reactivity with insulins of three species and blocking of insulin binding to its receptor." dans: Immunology letters, Vol. 8, Issue 5, pp. 279-83, (1985) (PubMed).

Détails sur Insulin

Antigène: Insulin (INS)

Autre désignation: Insulin (INS Produits)

Synonymes: anticorps IDDM2, anticorps ILPR, anticorps IRDN, anticorps MODY10, anticorps ins1, anticorps xins, anticorps ins1-a, anticorps Insulin, anticorps AA986540, anticorps Ins-2, anticorps InsII, anticorps Mody, anticorps Mody4, anticorps proinsulin, anticorps zgc:109842, anticorps igf2-A, anticorps ins, anticorps ins-a, anticorps ins-b, anticorps insulin, anticorps insulin precursor, anticorps insulin II, anticorps preproinsulin, anticorps insulin L homeolog, anticorps insulin S homeolog, anticorps INS, anticorps INS-IGF2, anticorps ins, anticorps Ins, anticorps PIN, anticorps Ins2, anticorps ins.L, anticorps ins.S

Sujet: Proinsulin,Insulin and glucagon are pancreatic endocrine hormones secreted by islet cells within the pancreas. The stimulus for insulin secretion is a HIGH blood glucose. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population.,IDDM, INS

ID gène: 3630

UniProt: P01308

Pathways: Signalisation NF-kappaB, Signalisation RTK, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Hormone Activity, Carbohydrate Homeostasis, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Autophagy, Negative Regulation of intrinsic apoptotic Signaling, Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation