ODF2 anticorps

N° du produit ABIN964608

Détail du produit anti-ODF2 anticorps

Antigène: ODF2 (Outer Dense Fiber of Sperm Tails 2 (ODF2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ODF2 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: This antibody was purified from monospecific antiserum by protein-A purified immunoaffinity chromatography. It is directed against, and shows specific reactivity for, human Cenexin-1 protein. A BLAST analysis was used to suggest cross-reactivity with Cenexin-1 from human, chimpanzee, mouse, rat, bovine sources based on 100% homology with the immunizing sequence. Reactivity with Cenexin-1 protein from other sources has not been determined.

Attributs du produit: This antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. Cenexin-1 (ODF84) and cenexin-2 are splicing variants that are expressed from the same genetic locus Outer Dense Fiber protein 2 (ODF2) . Cenexin-1 and cenexin-2, regarded as centriolar proteins. Cenexin-1, a 93-kD variant of ODF2, is the major form of cennexin expressed in various somatic cells and tissues and associates with centrosomes. Cenexin-1 contains a unique C-terminal extension that appears to play a critical role in recruiting mitotic regulators such as polo-like kinase 1. In contrast, ODF2, a 70-kDa protein, is a major component of sperm tail cytoskeleton and abundantly expressed in testis. Additional evidence suggests that both of these proteins play important role in primary cilia formation. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. Cenexin-1 is one of the major outer dense fiber proteins. Multiple protein isoforms are encoded by transcript variants of the cenexin gene, however, not all isoforms and variants have been fully described.

Purification: affinity purified

Stérilité: Sterile filtered

Immunogène: This protein-A purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a truncated recombinant protein hCenexin1.
Immunogen Type: RecombinantProtein

Isotype: IgG

Information d'application

Indications d'application: Anti-Cenexin-1 purified antibody has been tested for use in ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 93 kDa in size corresponding to Cenexin-1 by western blotting in the appropriate cell lysate or extract.

Commentaires:

Gene Name: ODF2

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.53 mg/mL

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C

Stockage commentaire: Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

Date de péremption: 12 months

Détails sur ODF2

Antigène: ODF2 (Outer Dense Fiber of Sperm Tails 2 (ODF2))

Autre désignation: Cenexin-1 (ODF2 Produits)

Synonymes: anticorps odf84, anticorps odf2/1, anticorps odf2/2, anticorps DKFZp469J0214, anticorps CT134, anticorps ODF2/1, anticorps ODF2/2, anticorps ODF84, anticorps si:dkey-228b2.4, anticorps AI848335, anticorps MMTEST29, anticorps outer dense fiber of sperm tails 2, anticorps outer dense fiber of sperm tails 2a, anticorps outer dense fiber of sperm tails 2 L homeolog, anticorps ODF2, anticorps odf2, anticorps odf2a, anticorps odf2.L, anticorps Odf2

Sujet: This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Cenexin-1 (ODF84) and cenexin-2 are splicing variants that are expressed from the same genetic locus Outer Dense Fiber protein 2 (ODF2) . Cenexin-1 and cenexin-2, regarded as centriolar proteins. Cenexin-1, a 93-kD variant of ODF2, is the major form of cennexin expressed in various somatic cells and tissues and associates with centrosomes. Cenexin-1 contains a unique C-terminal extension that appears to play a critical role in recruiting mitotic regulators such as polo-like kinase 1. In contrast, ODF2, a 70-kDa protein, is a major component of sperm tail cytoskeleton and abundantly expressed in testis. Additional evidence suggests that both of these proteins play important role in primary cilia formation. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation.  Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. Cenexin-1 is one of the major outer dense fiber proteins. Multiple protein isoforms are encoded by transcript variants of the cenexin gene; however, not all isoforms and variants have been fully described.
Synonyms: ODF84 antibody, Outer dense fiber of sperm tail 2 antibody, Cenexin1 variant 1 antibody, KKT 4 antibody

ID gène: 4957

NCBI Accession: NP_702915

UniProt: Q5BJF6

Pathways: M Phase