ADAMTS1 anticorps (C-Term)

N° du produit ABIN965511

Détail du produit anti-ADAMTS1 anticorps

Antigène: ADAMTS1 (ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 1 (ADAMTS1))

Épitope: C-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ADAMTS1 est non-conjugé

Application: Immunohistochemistry (IHC)

Purification: Purified by antigen-specific affinity chromatography.

Immunogène: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of mouse ADAMTS-1(A disintegrin and metalloproteinase with thrombospondin motifs 1)

Information d'application

Indications d'application: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Détails sur ADAMTS1

Antigène: ADAMTS1 (ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 1 (ADAMTS1))

Autre désignation: ADAMTS-1 (ADAMTS1 Produits)

Synonymes: anticorps c3-c5, anticorps meth1, anticorps xadamts1, anticorps C3-C5, anticorps METH1, anticorps ADAM-TS1, anticorps ADAMTS, anticorps ADAMTS-1, anticorps METH-1, anticorps adamts1, anticorps ADAM metallopeptidase with thrombospondin type 1 motif 1, anticorps ADAM metallopeptidase with thrombospondin type 1 motif, 1, anticorps a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1, anticorps ADAM metallopeptidase with thrombospondin type 1 motif 1 L homeolog, anticorps ADAMTS1, anticorps adamts1, anticorps Adamts1, anticorps adamts1.L

Sujet: ADAM-TS1 (A disintegrin and metalloproteinase with thrombospondin motifs 1) cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. ADAM-TS1 has angiogenic inhibitor activity. Active metalloprotease may be associated with various inflammatory processes as well as development of cancer cachexia. ADAM-TS1 may play a critical role in follicular rupture. ADAM-TS1 cleaves aggrecan at the 1691-Glu-|-Leu1692 site, within the chondroitin sulfate attachment domain. It binds 1 zinc ion per subunit. ADAM-TS1 is a secreted protein and is associated with the extracellular matrix.It is induced in vitro in colon adenocarcinoma cells by interleukin-1, or in vivo in kidney and heart by lipopolysaccharide and it is also induced by LH stimulation in granulose cells of preovulatory follicles. The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix. The precursor is cleaved by a furin endopeptidase. ADAM-TS1 contains 1 disintegrin domain, 1 peptidase M12B domain, and 3 TSP type-1 domains.

Pathways: SARS-CoV-2 Protein Interactome