ATM anticorps

N° du produit ABIN965618

L’anticorps Souris Monoclonal anti-ATM a été validé pour WB et ELISA. Il convient pour détecter ATM dans des échantillons de Humain. Il y a 3+ publications disponibles.

Aperçu rapide pour ATM anticorps (ABIN965618)

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ATM est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 5C5

Détail du produit anti-ATM anticorps

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of human ATM expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-ATM (ABIN965618)

Goodarzi, Noon, Deckbar, Ziv, Shiloh, Löbrich, Jeggo: "ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin." dans: Molecular cell, Vol. 31, Issue 2, pp. 167-77, (2008) (PubMed).

ORegan, Kiely, OGara: "Expression of the adenyl cyclase-encoding gene (cya) of Rhizobium meliloti F34: existence of two cya genes?" dans: Gene, Vol. 83, Issue 2, pp. 243-9, (1990) (PubMed).

Renkawitz, Beug, Graf, Matthias, Grez, Schütz: "Expression of a chicken lysozyme recombinant gene is regulated by progesterone and dexamethasone after microinjection into oviduct cells." dans: Cell, Vol. 31, Issue 1, pp. 167-76, (1983) (PubMed).

Détails sur ATM

Antigène: ATM (Ataxia Telangiectasia Mutated (ATM))

Autre désignation: ATM

Sujet: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.
Tissue specificity: Found in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, spleen, thymus, testis, ovary, small intestine, colon and leukocytes.
Synonyms: AT1, ATA, ATC, ATD, ATE, ATDC, TEL1, TELO1, MGC74674, DKFZp781A0353, ATM

Poids moléculaire: 351kDa

ID gène: 472

Pathways: Signalisation p53, Apoptose, Réparation de l'ADN, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus