Purified by antigen-specific affinity chromatography.
Immunogène
Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of mouse Divalent metal transporter 1 (DMT1)
anticorps DCT1, anticorps DMT1, anticorps NRAMP2, anticorps Nramp2, anticorps mk, anticorps van, anticorps Dmt1, anticorps ATNRAMP2, anticorps F8G22.4, anticorps F8G22_4, anticorps NRAMP metal ion transporter 2, anticorps dct1, anticorps dmt1, anticorps nramp2, anticorps SLC11A2, anticorps cb426, anticorps fa07b10, anticorps wu:fa07b10, anticorps zgc:136699, anticorps solute carrier family 11 member 2, anticorps solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2, anticorps NRAMP metal ion transporter 2, anticorps manganese transport protein, anticorps metal transporter Nramp2, anticorps solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2, anticorps SLC11A2, anticorps Slc11a2, anticorps NRAMP2, anticorps LOC9327403, anticorps slc11a2
Sujet
Divalent metal transporter 1(DMT1) mediates apical iron uptake into duodenal enterocytes and also transfers iron from the endosome into the cytosol after cellular uptake via the transferrin receptor. Hence, mutations in DMT1 cause systemic iron deficiency and anemia.