FGFR4 anticorps

N° du produit ABIN966140

Détail du produit anti-FGFR4 anticorps

Antigène: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FGFR4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Ascitic fluid

Immunogène: Purified recombinant fragment of FGFR4 expressed in E. Coli.

Clone: 4H2B10B2

Isotype: IgG1

Information d'application

Indications d'application: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Stockage

Format: Liquid

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Références pour anticorps anti-FGFR4 (ABIN966140)

Ezzat, Zheng, Winer, Asa: "Targeting N-cadherin through fibroblast growth factor receptor-4: distinct pathogenetic and therapeutic implications." dans: Molecular endocrinology (Baltimore, Md.), Vol. 20, Issue 11, pp. 2965-75, (2006) (PubMed).

Angelin: "Telling the liver (not) to make bile acids: a new voice from the gut?" dans: Cell metabolism, Vol. 2, Issue 4, pp. 209-10, (2005) (PubMed).

Détails sur FGFR4

Antigène: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Autre désignation: FGFR4 (FGFR4 Produits)

Synonymes: anticorps FGFR4, anticorps XFGFR-4, anticorps XFGFR-4a, anticorps cd334, anticorps fgfr-4, anticorps jtk2, anticorps tkf, anticorps xfgfr4, anticorps CD334, anticorps JTK2, anticorps TKF, anticorps Fgfr-4, anticorps etID309818.21, anticorps wu:fc13h10, anticorps zgc:111935, anticorps fgfr-4c, anticorps fgfr4, anticorps fibroblast growth factor receptor 4, anticorps fibroblast growth factor receptor 4 S homeolog, anticorps FGFR4, anticorps fgfr4, anticorps Fgfr4, anticorps fgfr4.S

Sujet: FGFR4 (fibroblast growth factor receptor 4) is part of a family of fibroblast growth factor receptors that mediate the biological functions of specific growth factors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane domain and a cytoplasmic kinase domain. Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues. These receptor proteins play a role in important processes such as cell division, regulating cell growth and maturation, formation of blood vessels, wound healing, and embryo development. Although specific functions of FGFR4 remain unclear, studies indicate that the gene is involved in muscle development and the maturation of bone cells in the skull. FGFR4 may also play a role in the development and maintenance of specialized cells (called foveal cones) in the light-sensitive layer (the retina) at the back of the eye.
Synonyms: TKF, JTK2, CD334, MGC20292

Poids moléculaire: 88kDa

ID gène: 2264

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding