Proteinase 3 (PRTN3) anticorps

Détails pour le produit réf. ABIN966909, Fournisseur: Connectez-vous pour afficher
Antigène
  • ela2
  • MGC132250
  • ACPA
  • AGP7
  • C-ANCA
  • CANCA
  • MBN
  • MBT
  • NP-4
  • NP4
  • P29
  • PR-3
  • PR3
  • mPR3
  • proteinase 3 L homeolog
  • proteinase 3
  • prtn3.L
  • PRTN3
  • Prtn3
Reactivité
Humain
147
9
8
1
1
1
Hôte
Souris
73
72
16
3
2
Clonalité (Clone)
Monoclonal ()
Conjugué
Inconjugué
15
13
6
5
5
5
Application
ELISA, Western Blotting (WB)
149
92
40
13
13
10
10
8
6
5
4
3
3
2
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène Purified recombinant fragment of human Proteinase 3 expressed in E. Coli.
Clone 3B4
Isotype IgG2b
Purification Antibodies are purified by protein G affinity chromatography.
Antigène
Autre désignation Proteinase 3 (PRTN3 Antibody Extrait)
Sujet Proteinase 3, also known as PRTN3. PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.
Synonyms: PRTN3, ACPA, CANCA
Poids moléculaire 28kDa
ID gène 5657
Indications d'application Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 50% glycerol
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Background publications Kantari, Pederzoli-Ribeil, Amir-Moazami, Gausson-Dorey, Moura, Lecomte, Benhamou, Witko-Sarsat: "Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis." dans: Blood, Vol. 110, Issue 12, pp. 4086-95, 2007 (PubMed).

Produit citée dans: Clin, Aubin, Parent, Ronsky, Labelle: "Biomechanical modeling of brace design." dans: Studies in health technology and informatics, Vol. 123, pp. 255-60, 2006 (PubMed).

Abdgawad, Hellmark, Gunnarsson, Westman, Segelmark: "Increased neutrophil membrane expression and plasma level of proteinase 3 in systemic vasculitis are not a consequence of the - 564 A/G promotor polymorphism." dans: Clinical and experimental immunology, Vol. 145, Issue 1, pp. 63-70, 2006 (PubMed).

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