Retinoblastoma 1 anticorps (RB1)

Details for Product anti-RB1 Antibody No. ABIN966949, Fournisseur: Connectez-vous pour afficher
Antigène
  • OSRC
  • RB
  • p105-Rb
  • pRb
  • pp110
  • DRB1
  • Rb
  • Rb-1
  • P105-RB
  • PP110
  • RB11
  • zgc:154147
  • RB transcriptional corepressor 1
  • RNA binding motif protein 45
  • retinoblastoma 1
  • RB1
  • RBM45
  • Rb1
  • rb1
Reactivité
Humain
631
343
237
10
9
8
8
5
5
4
4
3
3
3
2
Hôte
Souris
466
166
1
Clonalité (Clone)
Monoclonal ()
Conjugué
Cet anticorp Retinoblastoma 1 est non-conjugé
28
26
26
16
14
14
14
13
7
7
7
7
7
7
7
7
7
5
5
5
5
5
5
5
5
3
2
1
Application
Immunohistochemistry (IHC), ELISA
397
236
168
167
94
91
49
37
30
24
10
9
7
7
6
2
1
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène Purified recombinant fragment of human RB expressed in E. Coli.
Clone 7E4B8
Isotype IgG1
Purification Ascitic fluid
Autre désignation RB (RB1 Antibody Extrait)
Sujet The Rb protein regulates differentiation, apoptosis, and cell cycle control by coordinating the cell cycle at G1-S with transcriptional machinery. During G1, cyclin D-dependent kinase-mediated phosphorylation of Rb at Ser-795 marks the conversion of Rb from a transcriptionally repressive, hypophosphorylated state to an inactive, phosphorylated state, which may be sustained through mitosis by differential phosphorylation of up to 16 putative serine or threonine residues. Pediatric cancer retinoblastoma and the formation of other human tumors can be attributed to mutations in the retinoblastoma tumor suppressor gene(Rb).
Synonyms: RB, pRb, OSRC, pp110, p105-Rb, RB1
ID gène 5925
Pathways Cycle Cellulaire, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagy
Indications d'application Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock 4 °C
Background publications Barrientes, Cooke, Goodrich: "Glutamic acid mutagenesis of retinoblastoma protein phosphorylation sites has diverse effects on function." dans: Oncogene, Vol. 19, Issue 4, pp. 562-70, 2000 (PubMed).

Weinberg: "The retinoblastoma protein and cell cycle control." dans: Cell, Vol. 81, Issue 3, pp. 323-30, 1995 (PubMed).

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