Western Blot: 1: 500- 1: 2,000 IHC(P): 1: 500- 1: 2,000 IHC(F): 1: 500- 1: 2,000 ELISA: Propose dilution 1: 10,000. Determining optimal working dilutions by titration test.
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For Research Use only
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Surgucheva, McMahon, Surguchov: "gamma-synuclein has a dynamic intracellular localization." dans: Cell motility and the cytoskeleton, Vol. 63, Issue 8, pp. 447-58, (2006) (PubMed).
Antigène
SNCG (Breast Cancer-Specific Protein 1)
Sujet
SNCG(also designated gamma-synuclein or breast cancer-specific protein 1),with 127-amino acid protein(about 14kDa), belongs to the synuclein family, which also includes alpha- and beta- synuclein. Three synucleins are located in the neuronal cytosol and enriched in presynaptic terminals,while SNCG is also expressed in many other non-neuronal tissues. SNCG is abnormally expressed in a high percentage of tumor tissues of diversified cancer types, including liver, esophagus, colon, gastric, lung, prostate, cervical, and breast cancer, but rarely expressed in tumor-matched nonneoplastic adjacent tissues. High levels of SNCG have been identified in advanced breast carcinomas suggesting a correlation between overexpression of SNCG and breast tumor development.