Serotonin Receptor 2B anticorps (AA 1-58)

N° du produit ABIN967504

Cet anticorps Souris Monoclonal détecte spécifiquement Serotonin Receptor 2B dans WB et IHC. Il présente une réactivité envers Humain et Rat et a été mentionné dans 5+ publications.

Aperçu rapide pour Serotonin Receptor 2B anticorps (AA 1-58) (ABIN967504)

Antigène: Serotonin Receptor 2B (HTR2B)

Reactivité: Humain, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Serotonin Receptor 2B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: A72-1

Détail du produit anti-Serotonin Receptor 2B anticorps

Épitope: AA 1-58

Marque: BD Pharmingen™

Réactivité croisée: Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Please refer to us for technical protocols.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Human 5HT[2B]R (aa. 1-58) fusion protein

Isotype: IgG1 kappa

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store undiluted at 4°C.

Références pour anticorps anti-Serotonin Receptor 2B (ABIN967504)

Duxon, Flanigan, Reavley, Baxter, Blackburn, Fone: "Evidence for expression of the 5-hydroxytryptamine-2B receptor protein in the rat central nervous system." dans: Neuroscience, Vol. 76, Issue 2, pp. 323-9, (1997) (PubMed).

Saudou, Hen: "5-Hydroxytryptamine receptor subtypes in vertebrates and invertebrates." dans: Neurochemistry international, Vol. 25, Issue 6, pp. 503-32, (1995) (PubMed).

Pompeiano, Palacios, Mengod: "Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors." dans: Brain research. Molecular brain research, Vol. 23, Issue 1-2, pp. 163-78, (1994) (PubMed).

Humphrey, Hartig, Hoyer: "A proposed new nomenclature for 5-HT receptors." dans: Trends in pharmacological sciences, Vol. 14, Issue 6, pp. 233-6, (1993) (PubMed).

Foguet, Hoyer, Pardo, Parekh, Kluxen, Kalkman, Stühmer, Lübbert: "Cloning and functional characterization of the rat stomach fundus serotonin receptor." dans: The EMBO journal, Vol. 11, Issue 9, pp. 3481-7, (1992) (PubMed).

Détails sur Serotonin Receptor 2B

Antigène: Serotonin Receptor 2B (HTR2B)

Autre désignation: Serotonin Receptor 5-HT 2BR

Sujet: Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor, plays an important role in regulating diverse biological processes in the central and peripheral nervous systems, the cardiovascular system and the gastrointestinal systems. The different functions of serotonin are thought to be mediated through specific receptors. Physiological, biochemical, and pharmacological studies have defined at least fourteen serotonin receptors. The fourteen receptors are grouped in seven subtypes according to operational, structural, and transductional properties. The 5-HT2 receptors (5 -HT[2A]R, 5-HT[2B]R, an d 5-HT[2C]R) may be considered as prototypes for the study of serotonin receptors . Their functions are mediated by the second messenger inositol polyphosphate in a G-protein coupled pathway. They are expressed in diverse tissues including brain, vascular smooth muscles and platelets. The 5-HT[2A]R-mRNAs have been found in only a few areas of the brain, including the frontal cortex, piriform cortex, ventro-caudal part of CA3, motor cranial nerve nuclei in the brainstem, and the ventral horn of the spinal cord. The 5-HT[2C]R mRNA has been found at high levels in many parts of the brain including retrosplenial piriform and entorhinal cortex, anterior olfactory nucleus, substantia nigra pars compacta, several brainstem nuclei and the whole grey matter of the spinal cord. The 5-HT[2B]R was cloned in stomach fundus, where it is abundantly expressed.

Poids moléculaire: 45-55 kDa

Pathways: Signalistation JAK/STAT, Inositol Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Regulation of Carbohydrate Metabolic Process