C-JUN anticorps (pSer63)

N° du produit ABIN967578

Cet anticorps anti-C-JUN est un anticorps Souris Monoclonal détectant C-JUN dans WB et IHC (f). Adapté pour Humain, Souris et Rat. Ce Primary Antibody a été cité dans 7+ publications.

Aperçu rapide pour C-JUN anticorps (pSer63) (ABIN967578)

Antigène: C-JUN (JUN) (Jun Proto-Oncogene (JUN))

Reactivité: Humain, Souris, Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp C-JUN est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Clone: 2-c

Détail du produit anti-C-JUN anticorps

Épitope: pSer63

Marque: BD Pharmingen™

Réactivité croisée (Details): Predicted: Mouse, Rat

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotype: IgG1

Information d'application

Commentaires:

Related Products: ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20°C.

Références pour anticorps anti-C-JUN (ABIN967578)

Weiss, Bohmann: "Deregulated repression of c-Jun provides a potential link to its role in tumorigenesis." dans: Cell cycle (Georgetown, Tex.), Vol. 3, Issue 2, pp. 111-3, (2004) (PubMed).

Dunn, Wiltshire, MacLaren, Gillespie: "Molecular mechanism and biological functions of c-Jun N-terminal kinase signalling via the c-Jun transcription factor." dans: Cellular signalling, Vol. 14, Issue 7, pp. 585-93, (2002) (PubMed).

Shaulian, Karin: "AP-1 in cell proliferation and survival." dans: Oncogene, Vol. 20, Issue 19, pp. 2390-400, (2001) (PubMed).

Behrens, Sibilia, Wagner: "Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation." dans: Nature genetics, Vol. 21, Issue 3, pp. 326-9, (1999) (PubMed).

Wisdom, Johnson, Moore: "c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms." dans: The EMBO journal, Vol. 18, Issue 1, pp. 188-97, (1999) (PubMed).

Smeal, Binetruy, Mercola, Grover-Bardwick, Heidecker, Rapp, Karin: "Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73." dans: Molecular and cellular biology, Vol. 12, Issue 8, pp. 3507-13, (1992) (PubMed).

Lamph, Wamsley, Sassone-Corsi, Verma: "Induction of proto-oncogene JUN/AP-1 by serum and TPA." dans: Nature, Vol. 334, Issue 6183, pp. 629-31, (1988) (PubMed).

Détails sur C-JUN

Antigène: C-JUN (JUN) (Jun Proto-Oncogene (JUN))

Autre désignation: C-Jun

Sujet: The activator protein transcription factor (AP-1) was identified as a protein that recognizes specific sequences in the cis-control regions of the SV40 virus and the human metallothionein IIA gene. AP-1 is composed of protein products of two different gene families: jun and fos. The AP-1 transcription factor is either a homodimer of Jun proteins or a heterodimer of Jun and Fos proteins. The transcriptional activity of Jun is enhanced by phosphorylation of serines 63 (S63) and 73 in its activation domain. Phosphorylation at both sites is necessary for stimulating the activating function of Jun. Jun is phosphorylated by JNK protein kinases that are activated by the same signals that potentiate Jun activity.
The 2/c-Jun/(S63) monoclonal antibody recognizes the phosphorylated S63 of c-Jun.

Poids moléculaire: 39 kDa

Pathways: Signalisation MAPK, Signalisation RTK, Signalisation WNT, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Autophagy, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling, S100 Proteins