C-JUN anticorps (AA 26-175)

N° du produit ABIN967903

Cet anticorps Souris Monoclonal détecte spécifiquement C-JUN dans WB, IHC, IP et IF. Il présente une réactivité envers Humain, Souris, Rat, Poulet et Chien et a été mentionné dans 5+ publications.

Aperçu rapide pour C-JUN anticorps (AA 26-175) (ABIN967903)

Antigène: C-JUN (JUN) (Jun Proto-Oncogene (JUN))

Reactivité: Humain, Souris, Rat, Poulet, Chien

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp C-JUN est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Clone: 3-Jun

Détail du produit anti-C-JUN anticorps

Épitope: AA 26-175

Réactivité croisée: Humain, Poulet, Chien, Rat (Rattus)

Attributs du produit: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogène: Mouse c-Jun aa. 26-175

Isotype: IgG2a

Information d'application

Commentaires:

Related Products: ABIN968536, ABIN967389

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store undiluted at -20° C.

Références pour anticorps anti-C-JUN (ABIN967903)

Doray, Ghosh, Griffith, Geuze, Kornfeld: "Cooperation of GGAs and AP-1 in packaging MPRs at the trans-Golgi network." dans: Science (New York, N.Y.), Vol. 297, Issue 5587, pp. 1700-3, (2002) (PubMed).

He, Stepulak, Holmström, Omary, Eriksson: "The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase." dans: The Journal of biological chemistry, Vol. 277, Issue 13, pp. 10767-74, (2002) (PubMed).

Chang, Nakajima, Illenye, Lee, Honjo, Makiyama, Fujiwara, Mizuta, Sawai, Saida, Mitsui, Heintz, Magae: "Caspase-dependent apoptosis by ectopic expression of E2F-4." dans: Oncogene, Vol. 19, Issue 41, pp. 4713-20, (2000) (PubMed).

Taupin, Wu, Jeon, Devaney, Wang, Podolsky: "The trefoil gene family are coordinately expressed immediate-early genes: EGF receptor- and MAP kinase-dependent interregulation." dans: The Journal of clinical investigation, Vol. 103, Issue 9, pp. R31-8, (1999) (PubMed).

Lamph, Wamsley, Sassone-Corsi, Verma: "Induction of proto-oncogene JUN/AP-1 by serum and TPA." dans: Nature, Vol. 334, Issue 6183, pp. 629-31, (1988) (PubMed).

Détails sur C-JUN

Antigène: C-JUN (JUN) (Jun Proto-Oncogene (JUN))

Autre désignation: Jun

Sujet: The activator protein transcription factor (AP-1) was identified as a protein that recognizes specific sequences in the cis-control regions of the SV40 virus and the human metallothionein IIA gene. AP-1 is composed of protein products of two different gene families: jun and fos. The AP-1 transcription factor is either a homodimer of Jun proteins or a heterodimer of Jun and Fos proteins. The transcriptional activity of Jun is enhanced by phosphorylation in its activation domain at Ser63 and Ser73. Phosphorylation at both sites is necessary for stimulating the activating function of Jun. Jun is phosphorylated by JNK protein kinases that are activated by the same signals that potentiate Jun activity. This antibody is routinely tested by western blot analysis.

Poids moléculaire: 39 kDa

Pathways: Signalisation MAPK, Signalisation RTK, Signalisation WNT, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Autophagy, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling, S100 Proteins