FCER2 anticorps
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- Antigène Voir toutes FCER2 Anticorps
- FCER2 (Fc Fragment of IgE, Low Affinity II, Receptor For (CD23) (FCER2))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp FCER2 est non-conjugé
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Application
- Flow Cytometry (FACS), ELISA
- Purification
- purified
- Immunogène
- Purified recombinant fragment of human FCER2 expressed in E. coli.
- Clone
- 5B5
- Isotype
- IgG1
- Top Product
- Discover our top product FCER2 Anticorps primaire
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- Indications d'application
- ELISA: 1:10000, FCM: 1:200 - 1:400
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- 4°C, -20°C for long term storage
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Comparison of CD23 staining patterns in Merkel cell carcinoma and non-cutaneous small cell carcinoma." dans: Journal of cutaneous pathology, Vol. 36, Issue 2, pp. 206-10, (2009) (PubMed).
: "Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China." dans: Environmental and molecular mutagenesis, Vol. 50, Issue 4, pp. 285-90, (2009) (PubMed).
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Comparison of CD23 staining patterns in Merkel cell carcinoma and non-cutaneous small cell carcinoma." dans: Journal of cutaneous pathology, Vol. 36, Issue 2, pp. 206-10, (2009) (PubMed).
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- Antigène
- FCER2 (Fc Fragment of IgE, Low Affinity II, Receptor For (CD23) (FCER2))
- Autre désignation
- FCER2 (FCER2 Produits)
- Synonymes
- anticorps BLAST-2, anticorps CD23, anticorps CD23A, anticorps CLEC4J, anticorps FCE2, anticorps IGEBF, anticorps Fcer2a, anticorps Fc fragment of IgE receptor II, anticorps FCER2, anticorps Fcer2
- Sujet
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Description: The human leukocyte differentiation antigen CD23 (FCE2) is a key molecule for B-cell activation and growth. It is the low-affinity receptor for IgE. The truncated molecule can be secreted, then functioning as a potent mitogenic growth factor.(supplied by OMIM) . It is expressed on most mature, conventional B cells (but not on peritoneal CD5+ B cells), and can also be found on the surface of T cells, macrophages, platelets and EBV transformed B lymphoblasts. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic Lymphocytic leukemia. CD23 is expressed by B cells in the follicular mantle but not by proliferating germinal centre cells. CD23 is also expressed by eosinophils. CD23 is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a ""membrane bound cytokine," in that the soluble cleavage products of CD23 are themselves able to act as cytokines in vitro.
Aliases: CD23, FCE2, CD23A, IGEBF, CLEC4J, FCER2
- Poids moléculaire
- 37 kDa
- ID gène
- 2208
- HGNC
- 2208
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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