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Dermatoplasty can decrease spermatogenic cells and reduce Survivin protein expression.
Report survivin expression in the normal pancreas.
Survivin is important for optimal development of bovine blastocysts and confirm that survivin expression suppresses apoptosis of pre-implantation embryos.
Our findings identify survivin as a target of HO-1 (Montrer HMOX1 Protéines) and a mediator of adipocyte-induced survival in the metastatic niche.
High BIRC5 expression is associated with gefitinib resistance in lung cancer.
miR-203 expression also inhibited primary tumor growth in ovaries and metastatic tumors in multiple peritoneal organs including liver and spleen. miR-203 inhibits ovarian tumor metastasis by targeting BIRC5/survivin and attenuating the TGFbeta pathway.
Survivin may be implicated in the bcl-2 (Montrer BCL2 Protéines) and p53 (Montrer TP53 Protéines) pathways and therefore in the biology of PDAC. Its potential use as a survival predictor and therapeutic target represent a promising field.
Study in hepatocellular carcinoma cell line elicited a new mechanism in which IGF-1 induced epithelial-mesenchymal transition through regulation of survivin and a downstream pathway.
simvastatin significantly inhibited the proliferation and invasion of SACC83 cells, induced apoptosis, and reduced the expression of survivin, which suggests that simvastatin may be a novel target for salivary gland adenoid cystic carcinoma therapy.
Survivin is significantly up-regulated in hepatocellular carcinoma (HCC (Montrer FAM126A Protéines))tissues and associated with tumor growth and lymph node metastasis. Clinical detection of survivin level combined with MRI (Montrer C7ORF49 Protéines) examination might be beneficial for clinical diagnosis and treatment of HCC (Montrer FAM126A Protéines)
Our study identified the STAT3 (Montrer STAT3 Protéines) rs1053004 C/C as a high-risk genotype in MA with lower survivin and VEGF (Montrer VEGFA Protéines) transcription levels in the peripheral blood.
Overexpression of miR (Montrer MLXIP Protéines)-485-5p suppresses breast cancer progression and enhances chemosensitivity. Further study demonstrated that miR (Montrer MLXIP Protéines)-485-5p directly targeted the 3'-untranslated region of survivin and overexpression of survivin overcomes the miR (Montrer MLXIP Protéines)-485-5p induced effects on breast cancer.
Survivin expression in gastric cancer cells is regulated by DEC1 (Montrer BHLHE40 Protéines).
The present results indicated that PPARgamma (Montrer PPARG Protéines) may serve a protective role on bEnd.3 cells and that BIRC5 may be a downstream target of PPARgamma (Montrer PPARG Protéines) regulation during cerebral ischemia.
While induced by exposure to reactive oxygen species generating stresses, the ultimate expression of changes in radiation response is dependent upon the bi-functionality of the tumor associated protein survivin and its intracellular translocation.
HDL-associated sphingosine 1-phosphate inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression.
Survivin also attenuates DNA damage related to PARP activation and inhibits TNFalpha-induced lipolysis, suggesting that Survivin may facilitate adipocyte maintenance in response to inflammatory stimuli.
The study assigns a new meiotic function to Cullin9 and reveals that it prevents mouse eggs from aneuploidy by regulating microtubule dynamics via survivin.
this study shows that that sorafenib promotes the survival of bone marrow cells by up-regulating survivin
Survivin was regulated by TGF-beta (Montrer TGFB1 Protéines) and was found to be highly expressed during mucosal healing following intestinal inflammation
Survivin is a key regulator of gut (Montrer GUSB Protéines) tissue integrity by regulating epithelial homeostasis in the stem cell niche.
TGFbetaRI inhibition in an injured adult heart could both stimulate the autocrine/paracrine activity of survivin and inhibit Wnt (Montrer WNT2 Protéines) in CPCs to mediate cardioprotection and improve cardiac function.
Survivin is a key gene for regulating squamous cell carcinoma (SCC (Montrer CYP11A1 Protéines)) cancer stem cell formation and cancer SCC (Montrer CYP11A1 Protéines) development.
survivin2 is important in maintaining hematopoietic stem and lineage committed cells during zebrafish development, by virtue of its antiapoptotic activity in a caspase (Montrer CASP3 Protéines) dependent and cell autonomous fashion.
Survivin 2 was identified as a key regulator of neurogenesis, vasculo-angiogenesis, hematopoiesis and cardiogenesis.
This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
apoptosis inhibitor survivin
, baculoviral IAP repeat-containing 5 (survivin)
, baculoviral IAP repeat-containing protein 5
, baculoviral IAP repeat-containing 5
, apoptosis inhibitor 4
, survivin variant 3 alpha
, baculoviral IAP repeat containing 5b
, baculoviral IAP repeat-containing 5B
, survivin 2
, baculoviral IAP repeat containing 5 S homeolog
, baculoviral IAP repeat-containing 5, gene 2