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Human AGER Protein expressed in HEK-293 Cells - ABIN2180572
Xue, Rai, Singer, Chabierski, Xie, Reverdatto, Burz, Schmidt, Hoffmann, Shekhtman: Advanced glycation end product recognition by the receptor for AGEs. dans Structure (London, England : 1993) 2011
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Human AGER Protein expressed in Human Cells - ABIN2004453
Sugaya, Fukagawa, Matsumoto, Mita, Takahashi, Ando, Inoko, Ikemura et al.: Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart ... dans Genomics 1995
Show all 5 Pubmed References
Results show that RAGE is activated by HMGB1 (Montrer HMGB1 Protéines) to induce EMT (Montrer ITK Protéines) in prostate cancer cells.
high mobility group box 1 (Montrer HMGB1 Protéines)-receptor for advanced glycation end-products (HMGB1 (Montrer HMGB1 Protéines)-RAGE) signaling pathway may be involved in the pathogenesis of preterm premature rupture of the membranes (pPROM (Montrer SERPINH1 Protéines)).
Results show that RAGE is upregulated in breast cancer tissues, and confirmed that RAGE was a direct target of miR (Montrer MLXIP Protéines)-328.
The results suggest that S100A12 (Montrer S100A12 Protéines) does not participate in the induction of inflammation in dental pulp. However, RAGE can participate in the inflammation in the pulp of males.
The results show for the first time that RAGE is present in neuronally-derived plasma exosomes, and suggest that exosomal RAGE may be a novel biomarker that reflects pathophysiological processes in the brain.
Decreased soluble RAGE in neutrophilic asthma is correlated with disease severity and RAGE G82S variants.
Our study provides novel evidence for a potential role of AGER in bridging human papillomavirus (HPV)-induced inflammation and cervical cancer.
Plasmatic RAGE level is significantly lower in patients with prosthetic-joint-associated infections.
Inhibition of GLO1 (Montrer GLO1 Protéines) in Glioblastoma Multiforme Increases DNA-AGEs, Stimulates RAGE Expression, and Inhibits Brain Tumor Growth in Orthotopic Mouse Models
a significant association between RAGE gene rs1800624 and rs1800625 polymorphisms and Age-related macular degeneration risk, is reported.
microglial RAGE activation in presence of amyloid beta-enriched environment contributes to the entorhinal cortex vulnerability.
Established a murine model of myocardial ischemia-reperfusion injury; investigated and found remote ischemic postconditioning protects against IR injury thru RAGE-HMGB1 (Montrer HMGB1 Protéines) Pathway.
In this study, we found that the wnt (Montrer WNT2 Protéines) co-receptor Lrp6 (Montrer LRP6 Protéines) was a potent positive regulator of beta-catenin (Montrer CTNNB1 Protéines) signaling in TDI-induced asthma models, both in vivo and in vitro. Additionally, for the first time, we demonstrated that RAGE could mediate phosphorylation of Lrp6 (Montrer LRP6 Protéines), suggesting a functional cross talk between RAGE and the canonical wnt (Montrer WNT2 Protéines)/beta-catenin (Montrer CTNNB1 Protéines) signaling pathway involved in mediating beta-catenin (Montrer CTNNB1 Protéines) activation.
Chronic unpredictable stress (CUS) promotes significant morphological changes and causes robust upregulation of HMGB1 (Montrer HMGB1 Protéines) messenger RNA in enriched hippocampal microglia and robust and persistent upregulation of RAGE messenger RNA. CUS increased surface expression of RAGE protein on hippocampal microglia and anhedonic behavior. RAGE knockout mice were resilient to stress-induced anhedonia.
study found that diabetes predisposes to more severe infections because of additional inflammatory output through dual activation of MyD88 (Montrer MYD88 Protéines) by not only TLR4 (Montrer TLR4 Protéines) but also RAGE
RAGE controls myocardial dysfunction and oxidative stress in high-fat fed mice by sustaining mitochondrial dynamics and autophagy-lysosome pathway.
these data provide a previously uncharacterized in vivo mechanism contingent on oligodeoxy-nucleotide -administered dose, where TLR9 (Montrer TLR9 Protéines) governs the primary response and RAGE plays a distinct and cooperative function in providing a pivotal role in balancing the immune response.
data demonstrate that under the diabetic condition, DRG neurons are directly affected by elevated levels of glucose, independent of vascular or glial signals, and dependent on RAGE expression.
findings suggest that HMGB1 (Montrer HMGB1 Protéines) induces the transcytosis of albumin (Montrer ALB Protéines) via RAGE-dependent Src (Montrer SRC Protéines) phosphorylation and Cav-1 (Montrer CAV1 Protéines) phosphorylation. These studies revealed a new mechanism of HMGB1 (Montrer HMGB1 Protéines)-induced endothelial hyperpermeability.
data suggest that S100A8 (Montrer S100A8 Protéines)/A9 acts directly on BV-2 microglial cells via binding to TLR4 (Montrer TLR4 Protéines) and RAGE on the membrane and then stimulates the secretion of proinflammatory cytokines through ERK (Montrer EPHB2 Protéines) and JNK (Montrer MAPK8 Protéines)-mediated NF-kappaB (Montrer NFKB1 Protéines) activity in BV-2 microglial cells.
Our results suggested that the increased RAGE expression in inflammatory circumstances and interaction with AGEs are risk factors in decreasing of aggrecan (Montrer ACAN Protéines) content in nucleus pulposus.
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847).
RAGE isoform NtRAGE-delta
, RAGE isoform sRAGE-delta
, advanced glycation end-products receptor
, receptor for advanced glycosylation end products
, advanced glycosylation end product-specific receptor variant 2
, advanced glycosylation end product-specific receptor variant 3
, advanced glycosylation end product-specific receptor variant 4
, advanced glycosylation end product-specific receptor variant 5
, advanced glycosylation end product-specific receptor variant 1
, advanced glycosylation end product-specific receptor variant 6
, advanced glycosylation end product-specific receptor variant 7
, advanced glycosylation end product-specific receptor variant 8
, advanced glycation end product receptor
, advanced glycosylation end product-specific receptor
, MAPK/MAK/MRK overlapping kinase
, renal tumor antigen