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Human AGER Protein expressed in HEK-293 Cells - ABIN2180572
Xue, Rai, Singer, Chabierski, Xie, Reverdatto, Burz, Schmidt, Hoffmann, Shekhtman: Advanced glycation end product recognition by the receptor for AGEs. dans Structure (London, England : 1993) 2011
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Human AGER Protein expressed in Human Cells - ABIN2004453
Sugaya, Fukagawa, Matsumoto, Mita, Takahashi, Ando, Inoko, Ikemura et al.: Three genes in the human MHC class III region near the junction with the class II: gene for receptor of advanced glycosylation end products, PBX2 homeobox gene and a notch homolog, human counterpart ... dans Genomics 1995
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the G82S variant of the RAGE gene was significantly associated with an increased risk of all-cause mortality and acute myocardial infarction in the Chinese Han population.
both RAGE and mitochondrial damage primed NLRP3 (Montrer NLRP3 Protéines) and pro-IL-1beta (Montrer IL1B Protéines) activation as upstream signals of NF-kappaB (Montrer NFKB1 Protéines) activity, whereas mitochondrial damage was critical for the assembly of inflammasome components. These results revealed that accumulation of AGEs in NP tissue may initiate inflammation-related degeneration of the intervertebral disc via activation of the NLRP3 (Montrer NLRP3 Protéines) inflammasome.
The main mechanism of Integrin alphaXbeta2 I-domain binding to RAGE is a charge interaction, in which the acidic moieties of Integrin alphaXbeta2 I-domains, including E244, and D249, recognize the basic residues on the RAGE V-domain encompassing K39, K43, K44, R104, and K107.
An overexpression of the receptor for RAGE was found in lesioned samples of patients with acquired reactive perforating collagenosis.
Single-nucleotide polymorphism in RAGE gene and high circulating soluble RAGE level is associated with diabetic kidney disease.
Significant association of the RAGE system with Hashimoto's thyroiditis was found only with regard to the prevalence of the -429T>C, but not with -374T>A polymorphism.
study revealed an early and constant increase of sRAGE level in the CSF (Montrer CSF2 Protéines) of aneurysmal subarachnoid haemorrhage patients.
IL-23 (Montrer IL23A Protéines), alone and in combination with IL-18 (Montrer IL18 Protéines) and sRAGE, identified bacterial meningitis with excellent accuracy. Following validation, these markers could aid clinicians in diagnosis of bacterial meningitis and decision-making regarding prolongation of antibiotic therapy
meta-analysis aimed at investigating whether the RAGE rs2070600 polymorphism is associated with cancer risk
found that S100B (Montrer S100B Protéines) plays a crucial role in blocking the interaction site between RAGE V domain and S100A1 (Montrer S100A1 Protéines). A cell proliferation assay WST (Montrer EEF1A2 Protéines)-1 also supported our results. This report could potentially be useful for new protein development for cancer treatment
data suggest that S100A8 (Montrer S100A8 Protéines)/A9 acts directly on BV-2 microglial cells via binding to TLR4 (Montrer TLR4 Protéines) and RAGE on the membrane and then stimulates the secretion of proinflammatory cytokines through ERK (Montrer EPHB2 Protéines) and JNK (Montrer MAPK8 Protéines)-mediated NF-kappaB (Montrer NFKB1 Protéines) activity in BV-2 microglial cells.
Activation of RAGE facilitates the development of hypoxia-induced pulmonary hypertension by increasing ECM (Montrer MMRN1 Protéines) deposition in pulmonary arteries.
knockout of RAGE significantly ameliorates mainstream cigarette smoke-induced airway inflammation in mice
Here, the authors show that RAGE deficiency impairs anti-viral immunity during an early-life infection with pneumonia virus of mice (PVM; a murine analogue of RSV). The elevated viral load was associated with the release of high mobility group box-1 (HMGB1 (Montrer HMGB1 Protéines)) which triggered airway smooth muscle remodelling in early-life.
We investigated the role of RAGE in postischaemic leukocyte adhesion after myocardial infarction and its effect on postischaemic myocardial function. RAGE represents an additional pro-inflammatory endothelial mediator of ischaemia-reperfusion injury.
The results indicate that cells respond to advanced glycation end products by increasing matrix assembly and that RAGE is involved in this response.
Receptor for AGE expression and reactive oxygen species production were upregulated in db/db (Montrer LEPR Protéines) mouse livers, together with impaired proteolytic, antioxidant and mitochondrial respiratory activities. In parallel, acute exposure of HepG2 cells to glycated albumin (Montrer ALB Protéines) also elicited intracellular free radical formation
RAGE is phosphorylated by the ATM (Montrer ATM Protéines) kinase and is recruited to the site of DNA-double-strand break via an early DNA damage response.
receptor for advanced glycation end products (RAGE) was required for stabilization of beta-catenin (Montrer CTNNB1 Protéines) in toluene diisocyanate-induced asthma, identifying protective effects of RAGE blockade in this mouse model
perturbation of Bone marrow mesenchymal stromal cells in diabetes mellitus could be partially explained by chronic RAGE signaling.
Our results suggested that the increased RAGE expression in inflammatory circumstances and interaction with AGEs are risk factors in decreasing of aggrecan (Montrer ACAN Protéines) content in nucleus pulposus.
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847).
RAGE isoform NtRAGE-delta
, RAGE isoform sRAGE-delta
, advanced glycation end-products receptor
, receptor for advanced glycosylation end products
, advanced glycosylation end product-specific receptor variant 2
, advanced glycosylation end product-specific receptor variant 3
, advanced glycosylation end product-specific receptor variant 4
, advanced glycosylation end product-specific receptor variant 5
, advanced glycosylation end product-specific receptor variant 1
, advanced glycosylation end product-specific receptor variant 6
, advanced glycosylation end product-specific receptor variant 7
, advanced glycosylation end product-specific receptor variant 8
, advanced glycation end product receptor
, advanced glycosylation end product-specific receptor
, MAPK/MAK/MRK overlapping kinase
, renal tumor antigen