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PAR3 is essential in thrombin (Montrer F2 Protéines) stimulated insulin (Montrer INS Protéines) secretion.
TFRGAP, a PAR-3 mimicking peptide significantly induced the phosphorylation of eNOS (Montrer NOS3 Protéines)-Thr (Montrer TRH Protéines)-495 with minimal phosphorylation of eNOS (Montrer NOS3 Protéines)-Ser (Montrer SIGLEC1 Protéines)-1177 with no change in nitric oxide production.
These data provide intriguing novel insights into the diversification of functional selectivity of protease signaling achievable by canonical and noncanonical PAR (Montrer JTB Protéines) activation, such as the activation of vascular-protective Tie2 (Montrer TEK Protéines) by noncanonical PAR3 activation.
In pancreatic adenocarcinoma cells, PAR3 knockdown enhances cell adhesion. We propose this is due to increased expression of E-cadherin (Montrer CDH1 Protéines), leading to a greater adhesion of free-floating cells to cells bound to the surface via integrins, particularly ITGalphav.
Data indicate that knockdowns of all three PARs (Montrer EPRS Protéines) PAR-1 (Montrer MARK2 Protéines), PAR-2 (Montrer F2RL1 Protéines), and PAR-3 exhibited changes in the expression of CDC42 (Montrer CDC42 Protéines), which correlated with the changes in their invasion.
Elevated expression of PAR-3, b (Montrer MARK2 Protéines)ut not PAR-4, was detected in the lungs of idiopathic pulmonary fibrosis patients.
A unique contributory role for PAR3 in the complex mechanisms underlying Activated protein C (Montrer PROC Protéines) cytoprotective effects.
PAR-3 receptors interact with thrombin (Montrer F2 Protéines) and increase heme oxygenase-1 (Montrer HMOX1 Protéines) expression in synovial fibroblasts.
Human PAR-3 is regulated post-transcriptionally via the mRNA-stabilizing factor HuR (Montrer ELAVL1 Protéines), whereas transcriptional control involves nuclear factor of activated T cells (NFAT (Montrer NFATC1 Protéines)).
FXa (Montrer F10 Protéines) bound in a punctate manner to thrombi under shear, while thrombin (Montrer F2 Protéines) and fibrin(ogen) distributed ubiquitously over platelet-fibrin thrombi
Data show that activated protein C (Montrer PROC Protéines) signals via protease activated receptors PAR2 (Montrer F2RL1 Protéines)/PAR3 to expand Treg cells, mitigating the disease in mice.
found a hypomethylated region mapping to Iqgap2 (IQ motif-containing GTPase activating protein 2 (Montrer IQGAP2 Protéines)) and F2rl2
Simultaneous depletion of PAR-1 (Montrer MARK2 Protéines) and PAR-3 almost completely inhibited epithelial-mesenchymal transition in bleomycin-induced lung fibrosis.
these data point to a novel kallikrein 6 (Montrer KLK1 Protéines) -signaling axis in neurons that is mediated by PAR1 (Montrer F2R Protéines) and PAR2 (Montrer F2RL1 Protéines) and is positioned to contribute to neurodegeneration
Par3(-/-) mice were protected against ferric chloride-induced thrombosis of mesenteric arterioles and against thromboplastin (Montrer F3 Protéines)-induced pulmonary embolism (protease-activated receptor-3 (PAR3)
PAR3 receptors and analogues can mediate cell signaling by interaction with PAR1 (Montrer F2R Protéines)-type thrombin (Montrer F2 Protéines) receptors
Crystal structures reveal the molecular basis of the cofactor function of cleaved PAR3, bound to exosite I, on recognition of PAR4 (Montrer F2RL3 Protéines) by the active site of thrombin (Montrer F2 Protéines).
This gene encodes a member of the protease-activated receptor (PAR) family which is a subfamily of the seven transmembrane G protein-coupled cell surface receptor family. The encoded protein acts as a cofactor in the thrombin-mediated cleavage and activation of the protease-activated receptor family member PAR4. The encoded protein plays an essential role in hemostasis and thrombosis. Alternate splicing results in multiple transcript variants that encode different isoforms.
Coagulation factor II receptor-like 2 (protease-actovated receptor 3)
, protease-activated receptor 3
, proteinase-activated receptor 3
, proteinase-activated receptor-3
, thrombin receptor-like 2
, Proteinase activated receptor 3 precursor (PAR-3) (Thrombin receptor-like 2) (Coagulation factor II receptor-like 2)
, coagulation factor II receptor-like 2
, coagulation factor II (thrombin) receptor-like 2 L homeolog