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nectin-4 serves as a stimulatory co-receptor for the prolactin receptor by regulating the feedback inhibition of SOCS1 in the JAK2-STAT5a signaling pathway
Novel type of cell adhesion apparatus is mediated by Nectin-1 and Nectin-4. It's implicated in prolactin receptor signaling for mammary gland development.
Pvrl1 is a bona fide target gene of the transcription factor p63, whereas Pvrl4 regulation is linked to epidermal differentiation and is under Irf6
Mouse PVRL4 functions less efficiently as a receptor for measles virus than the human homologue.
Ectodermal dysplasia-syndactyly syndrome is the second known "nectinopathy" caused by mutations in a nectin adhesion molecule.
novel homozygous missense variant in NECTIN4 causing ectodermal dysplasia cutaneous syndactyly syndrome in a consanguineous Pakistani family
There are as yet unknown factors that induce NECTIN4 overexpression in trophoblast cells that may contribute to abnormal placentation via an aberrant immune response and the onset of a preeclamptic pregnancy.
soluble nectin-4 ecto-domain promotes breast cancer induced angiogenesis via endothelial Integrin-beta4
that Nectin-4 had a promoter effect on human gastric cancer cell growth and motility
We suggest that Nectin-4 is a relevant prognostic factor and a therapeutic target in luminalB (HER2 negative) breast cancer.
Nectin-4 promotes cell-cell adhesion/aggregation, migration, and proliferation of ovarian tumor cells.
Nectin-4 is not only a BCSC marker but also a breast cancer metastasis marker
This study suggests that PVRL4 is post-transcriptionally regulated by miR-128 and miR-31.
High Nectin-4 expression is associated with neoplasms.
We show that Measles virus gains entry into MCF7, DLD-1, and HTB-20 cancer cells through a PVRL4-mediated macropinocytosis pathway and identified the typical cellular GTPase and kinase involved.
Nectin-4 is both a new promising prognostic biomarker and specific therapeutic target for Triple-negative breast cancers
ADAM17 and ADAM10 cleave Nectin-4 and release soluble Nectin-4 (sN4).
The data presented in this study suggested that nectin-4 may be a therapeutic target for systemic lupus erythematous through affecting the cell apoptosis
Nectin-4 is critical for gallbladder cancer cell progression via PI3K/AKT pathway activation of Rac1.
Nectin-4 expression, when compared with control group, was higher in endometriotic lesions of patients having ovarian endometriosis and peritoneal endometriosis. This difference was significant in the endometrium of patients having endometriosis.
Transformation of breast cancer cells is dependent on PVRL4.
Nectin-4 is a significant prognostic predictor, and may play a critical role in pancreatic cancer. Nectin-4 may be novel therapeutic target for pancreatic cancer.
In airway epithelial cells, measles virus spread requires the nectin-4/afadin complex and is based on cytoplasm transfer between columnar cells.
The present study described clinical investigation of the EDSS1 identified in a large consanguineous family; DNA sequence analysis revealed a novel homozygous nonsense mutation (181C>T, p.Asp61*) in the PVRL4 gene.
This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.
poliovirus receptor-related 4
, poliovirus receptor-related protein 4-like
, ig superfamily receptor LNIR
, nectin 4
, poliovirus receptor-related protein 4
, Ig superfamily receptor LNIR