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Human Polyclonal PGK1 Primary Antibody pour IHC (p), ELISA - ABIN542998
Shetty, Muniyappa, Halady, Idell: Regulation of urokinase receptor expression by phosphoglycerate kinase. dans American journal of respiratory cell and molecular biology 2004
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Yeast (Saccharomyces cerevisiae) Polyclonal PGK1 Primary Antibody pour DB, EIA - ABIN568371
Kayatekin, Amasino, Gaglia, Flannick, Bonner, Fanning, Narayan, Barrasa, Pincus, Landgraf, Nelson, Hesse, Costanzo, Myers, Boone, Florez, Lindquist: Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity. dans Cell 2019
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Human Polyclonal PGK1 Primary Antibody pour ELISA, WB - ABIN543580
West, Moore, Biskup, Bugayenko, Smith, Ross, Dawson, Dawson: Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. dans Proceedings of the National Academy of Sciences of the United States of America 2005
Mouse (Murine) Polyclonal PGK1 Primary Antibody pour IHC, WB - ABIN3022690
Zhang, Yu, Chu, Wang, Xiong, Cai, Liu, Gao, Tao, Li, Li, Liang, Yang: Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis. dans Molecular cell 2018
Human Polyclonal PGK1 Primary Antibody pour ELISA, ICC - ABIN4345073
Khurana, Laskar, Bhattacharyya, Bhattacharyya: Hsp90 induces increased genomic instability toward DNA-damaging agents by tuning down RAD53 transcription. dans Molecular biology of the cell 2016
We propose that PGK1 mediates DNA repair and methylation through the HSP90/ERK pathway, and eventually enhances the chemoresistance to cisplatin. The results provide new insights on functions of PGK1 and HSP90, which might make them as promising targets for endometrial cancer chemotherapy.
Mechanistic investigations showed that Rab11-FIP2 interacted with the glycolytic kinase PGK1 and promoted its ubiquitination in NSCLC cells, leading to inactivation of the oncogenic AKT/mTOR signaling pathway.
CDC7-bound PGK1 converts ADP to ATP, thereby abrogating the inhibitory effect of ADP on CDC7-ASK activity, promoting the recruitment of DNA helicase to replication origins, DNA replication, cell proliferation, and brain tumorigenesis.
PGK1 is involved in the regulation of metastasis and invasion of HCC[ hepatocellular carcinoma] cells and can promote the migration and invasion of HCC cells. Therefore, PGK1 may be an important predictor of prognosis and postoperative recurrence in patients with liver cancer.
PGK1 T243 phosphorylation regulates the direction of PGK1-catalyzed reaction. Inhibition of PGK1 T243 phosphorylation abrogates protumoral function of macrophages. PGK1 T243 phosphorylation correlates with grades and prognosis of glioblastoma multiforme patients
High PGK1 expression was associated with poor prognosis in breast cancer, because PGK1 and HIF-1alpha formed a positive feed-forward loop and thus stimulated breast cancer progression and metastases.
PGK1 mutated variants display different catalytic activity and conformational stability compared to the native enzyme.
The results indicate that ALDOA and PGK1 may indicate resistance to cisplatin in osteosarcoma
PGK1 is used to indicate the prognosis of hepatocellular carcinoma (HCC).
Data show that LINC00963 (MetaLnc9) interacted with the glycolytic kinase PGK1 and prevented its ubiquitination in non-small cell lung cancer (NSCLC) cells, leading to activation of the oncogenic AKT/mTOR signaling pathway.
Acetylated PGK1 binds to and phosphorylates Beclin1 at S30, leading to activation of the VPS34-Beclin1 complex to initiate autophagosomal formation.
Data suggest that, in breast cancer cells, MYC acts as an upstream regulator leading to PGK1 activation. (MYC, proto-oncogene c-myc; PGK1, phosphoglycerate kinase 1)
PGK1, a glycolytic enzyme catalyzing the conversion of 3-phosphoglycerate into 2-phosphoglycerate, has increased expression in synovial tissues and blood of rheumatoid arthritis, which may be involved in pro-inflammation and synovial hyperplasia of the disease
In neuroblastoma cells, CAIX and PGK1 expression is up regulated under hypoxia and correlates with response to targeted anti-proliferative treatment.
Mitochindrial PGK1 acts as a protein kinase in coordinating glycolysis and the tricarboxylic acid cycle, which is instrumental in cancer metabolism and tumorigenesis.
PI3K/AKT/mTOR pathway regulates HDAC3 S424 phosphorylation, which promotes HDAC3-PGK1 interaction and PGK1 K220 deacetylation
Retinal dystrophy may be one of the clinical manifestations of phosphoglycerate kinase deficiency.
mutations associated with hPGK1 deficiency lead to increased aggregation and proteolysis rates in vitro and inside cells due to protein thermodynamic destabilization
Results show that PGK1 mRNA and protein expression were significantly increased in breast cancer tissues and can be considered as a prognostic biomarker of chemoresistance to paclitaxel treatment in breast cancer.
Suppression of PGK1 enhanced the radiosensitivity of U251 xenografts and suggest that PGK1 may serve as a useful target in the treatment of radioresistant glioma.
Pgk1 overexpression, or treatment with terazosin (an FDA-approved small molecule that binds and activates Pgk1), rescued motor axon phenotypes in SMA zebrafish. We conclude that global bioenergetics pathways can be therapeutically manipulated to ameliorate SMA motor neuron phenotypes in vivo.
Phosphoglycerate kinase is a moonlighting protein that functions as both a glycolytic enzyme and a disulfide reductase.
Purification and characterization of 3-phosphoglycerate kinase from Ehrlich ascites carcinoma cells
PGK domain movement and catalysis is regulated by a spring-loaded release mechanism
Results indicate that COX-2 suppression by PGK-1 is independent of its catalytic activity.
Together, these data suggest that PGK1 secreted by PCa regulates bone formation at the metastatic site by increasing osteoblastic activity, decreasing osteoclastic function, and expressing an osteoblastic phenotype by PCa cells.
Heterozygous for the X-linked pgk-1a and pgk-1b. Clonally heterotypic glands with inactive X-specific methylation were present in the adult murine stomach.
Pgk1 is strongly expressed in the developing tooth germ of the mouse lower first molar.
Findings indicate that overexpression of PGK-1 in LLC-1 reduces the COX-2 expression, and, in turn, affect PGE2, cell invasion, angiogenesis, and the immune functions, and finally inhibit the tumor progression.
targeting of a single bioenergetic protein, phosphoglycerate kinase 1 (Pgk1), was found to modulate motor neuron vulnerability in vivo. Knockdown of pgk1 alone was sufficient to partially mimic the SMA phenotype in wild-type zebrafish
present in, and accounts for, glycolysis and glutamate accumulation into synaptic vesicles
PGK1 role in metabolism and growth.
PGK1 (phosphoglycerate kinase 1) interacts with AtFtsZ2 in planta, suggesting a possible role in FtsZ phosphorylation.
The protein encoded by this gene is a glycolytic enzyme that catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. The encoded protein may also act as a cofactor for polymerase alpha. This gene lies on the X-chromosome, while a related pseudogene also has been found on the X-chromosome and another on chromosome 19.
, cell migration-inducing gene 10 protein
, primer recognition protein 2
, phosphoglycerate kinase
, phosphoglycerate kinase 1
, phosphoglycerate kinase 2