anti-Cobaye AIRE anticorps pour Immunohistochemistry

Recommended AIRE Antibody (fourni par: Connectez-vous pour afficher )

Antigène
Autoimmune Regulator (AIRE) Anticorps
  • AIRE1
  • APECED
  • APS1
  • APSI
  • PGA1
  • autoimmune regulator
  • autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
  • AaeL_AAEL013794
  • CpipJ_CPIJ001208
  • CpipJ_CPIJ001209
  • AIRE
  • Aire
Épitope
N-Term
39
19
16
13
13
11
6
4
4
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Reactivité
Boeuf (Vache), Chien, Cobaye, Cheval, Humain, Souris, Rat (Rattus)
171
81
30
10
8
7
6
4
3
2
1
Hôte
Lapin
117
60
16
2
1
Clonalité
Polyclonal
Conjugué
Cet anticorp AIRE est non-conjugé
7
6
6
6
5
5
2
2
2
2
2
2
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
167
107
50
41
18
17
16
11
5
5
4
2
1
1
1
Options
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N° du produit ABIN2779777
$ 289.00
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Fournisseur Clonality References Details
8.460051 ABIN2615294 IHC IHC (p) WB Rabbit IgG N-Term Connectez-vous pour afficher Polyclonal 0

General

Antigène Autoimmune Regulator (AIRE) Anticorps
Épitope N-Term
(39), (19), (16), (13), (13), (11), (6), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivité Boeuf (Vache), Chien, Cobaye, Cheval, Humain, Souris, Rat (Rattus)
(171), (81), (30), (10), (8), (7), (6), (4), (3), (2), (1)
Hôte Lapin
(117), (60), (16), (2), (1)
Clonalité
Polyclonal
Conjugué Cet anticorp AIRE est non-conjugé
(7), (6), (6), (6), (5), (5), (2), (2), (2), (2), (2), (2), (1)
Application Immunohistochemistry (IHC), Western Blotting (WB)
(167), (107), (50), (41), (18), (17), (16), (11), (5), (5), (4), (2), (1), (1), (1)
Pubmed 2 références disponible
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Détail du produit anti-AIRE anticorps

Détail du antigène AIRE Information d'application Stockage References for anti-AIRE antibody (ABIN2779777) Images
Blocking Peptide Blocking peptide for this product available: ABIN973041
Séquence HRTEIAVAVD SAFPLLHALA DHDVVPEDKF QETLHLKEKE GCPQAFHALL
Homologie Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%
Attributs du produit This is a rabbit polyclonal antibody against AIRE. It was validated on Western Blot and immunohistochemistry.
Purification Affinity Purified
Immunogène The immunogen is a synthetic peptide directed towards the N terminal region of human AIRE
Plasmids, Primers & others

Détail du antigène AIRE

Détail du produit anti-AIRE anticorps Information d'application Stockage References for anti-AIRE antibody (ABIN2779777) Images Haut de la page
Antigène
Autre désignation AIRE (AIRE Antibody Extrait)
Sujet The function of the protein encoded by the AIRE gene is not well defined. However it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Defects in this gene cause the autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Alias Symbols: AIRE1, APECED, APS1, APSI, PGA1
Protein Interaction Partner: TUBB, RAVER1, TUBA1C, TMPRSS13, CCDC87, FAT1, GIGYF2, SRRM2, TUBB4B, EIF4EBP3, UBB, HSP90AB1, HSPA8, HSPA5, HSPA1L, HSPA1A, ATP4A, HIST3H3, HDAC2, HDAC1, DAXX, AIRE, UBAC1, HIST1H3A, HIST2H2BE, HSPA4, SRSF1, SMC1A, XPO1, TOP2A, SSRP1, SNRPD3, SNRPB, SRSF3
Protein Size: 545
Poids moléculaire 58 kDa
ID gène 326
NCBI Accession NM_000383, NP_000374
UniProt O43918
Pathways Chromatin Binding

Information d'application

Détail du produit anti-AIRE anticorps Détail du antigène AIRE Stockage References for anti-AIRE antibody (ABIN2779777) Images Haut de la page
Indications d'application Optimal working dilutions should be determined experimentally by the investigator.
Commentaires

Antigen size: 545 AA

Restrictions For Research Use only

Stockage

Détail du produit anti-AIRE anticorps Détail du antigène AIRE Information d'application References for anti-AIRE antibody (ABIN2779777) Images Haut de la page
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freeze-thaw cycles.
Stock -20 °C
Stockage commentaire For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

References for anti-AIRE antibody (ABIN2779777)

Détail du produit anti-AIRE anticorps Détail du antigène AIRE Information d'application Stockage Images Haut de la page
Background publications

Ilmarinen, Kangas, Kytömaa, Eskelin, Saharinen, Seeler, Tanhuanpää, Chan, Slattery, Alakurtti, Palvimo, Ulmanen: "Functional interaction of AIRE with PIAS1 in transcriptional regulation." dans: Molecular immunology, Vol. 45, Issue 7, pp. 1847-62, 2008

Akiyoshi, Hatakeyama, Pitkänen, Mouri, Doucas, Kudoh, Tsurugaya, Uchida, Matsushima, Oshikawa, Nakayama, Shimizu, Peterson, Matsumoto: "Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner." dans: The Journal of biological chemistry, Vol. 279, Issue 32, pp. 33984-91, 2004

Images

Détail du produit anti-AIRE anticorps Détail du antigène AIRE Information d'application Stockage References for anti-AIRE antibody (ABIN2779777) Haut de la page
Images (Fournisseur)
Western Blotting (WB) image for anti-Autoimmune Regulator (AIRE) (N-Term) antibody (ABIN2779777) WB Suggested Anti-AIRE Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Pos...
 image for anti-Autoimmune Regulator (AIRE) (N-Term) antibody (ABIN2779777) anti-Autoimmune Regulator (AIRE) (N-Term) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-Autoimmune Regulator (AIRE) (N-Term) antibody (ABIN2779777) Rabbit Anti-AIRE Antibody Paraffin Embedded Tissue: Human Kidney Cellular Data: Epit...
Western Blotting (WB) image for anti-Autoimmune Regulator (AIRE) (N-Term) antibody (ABIN2779777) AIRE Antibody - N-terminal region (ARP32650_P050) validated by WB using human LCL at ...
Western Blotting (WB) image for anti-Autoimmune Regulator (AIRE) (N-Term) antibody (ABIN2779777) WB Suggested Anti-AIRE
Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500 ...
Western Blotting (WB) image for anti-Autoimmune Regulator (AIRE) (N-Term) antibody (ABIN2779777) Host: Rabbit Target Name: AIRE Sample Tissue: Mouse Skeletal Muscle Antibody Di...