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anti-Human Aurora Kinase C Anticorps:
anti-Mouse (Murine) Aurora Kinase C Anticorps:
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Human Polyclonal Aurora Kinase C Primary Antibody pour WB - ABIN1882164
Kimura, Matsuda, Yoshioka, Okano: Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3. dans The Journal of biological chemistry 1999
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Human Polyclonal Aurora Kinase C Primary Antibody pour ELISA, WB - ABIN4282476
Dieterich, Zouari, Harbuz, Vialard, Martinez, Bellayou, Prisant, Zoghmar, Guichaoua, Koscinski, Kharouf, Noruzinia, Nadifi, Sefiani, Lornage, Zahi, Viville, Sèle, Jouk, Jacob, Escalier, Nikas et al.: The Aurora Kinase C c.144delC mutation causes meiosis I arrest in men and is frequent in the North African population. ... dans Human molecular genetics 2009
Cow (Bovine) Polyclonal Aurora Kinase C Primary Antibody pour WB - ABIN2785453
Lee, Lim, Park, Lee, Han, Kim, Cheang, Lee, Lee, Ko, Jang, Kim, Miniaci, Bartsch, Kim, Bailey, Kandel, Kaang: Nuclear translocation of CAM-associated protein activates transcription for long-term facilitation in Aplysia. dans Cell 2007
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Human Polyclonal Aurora Kinase C Primary Antibody pour WB - ABIN390979
Burum-Auensen, Skotheim, Schjølberg, Røislien, Lothe, Clausen: Spindle proteins are differentially expressed in the various histological subtypes of testicular germ cell tumors. dans Journal of carcinogenesis 2010
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Human Polyclonal Aurora Kinase C Primary Antibody pour WB - ABIN4890463
Doyle, Lee, Selesniemi, Styer, Rueda: The impact of vitrification on murine germinal vesicle oocyte In vitro maturation and aurora kinase A protein expression. dans Journal of assisted reproduction and genetics 2014
Aurora-C interactions with members of the Chromosome Passenger Complex (CPC), Survivin (Montrer BIRC5 Anticorps) and Inner Centromere Protein (INCENP (Montrer INCENP Anticorps)) in reference to known Aurora-B (Montrer AURKB Anticorps) interactions to understand the functional significance of Aurora-C overexpression in human cancer cells, is reported.
Patients presenting with a monomorphic teratozoospermia such as globozoospermia or macrospermia with more than 85% of the spermatozoa presenting this specific abnormality have been analyzed permitting to identify several key genes for spermatogenesis such as AURKC and DPY19L2 (Montrer DPY19L2 Anticorps).
Homozygous c.144delC mutation in AURKC gene in infertile men with macrozoospermia in the Tunisian population
AURKC mutations are more frequent than Klinefelter syndrome and constitute the leading genetic cause of infertility in North African men.
Low AURKC expression is associated with cancer.
Overexpression of AURKC is associated with breast tumors.
Data indicate that the selective Aurora A (Montrer AURKA Anticorps), B, and C inhibitor SAR156497 showed antineoplastic activity in HCT116 cell xenograft model.
This review will describe the functions of each Aurora kinase (Montrer AURKA Anticorps) which include Aurora A (AURKA (Montrer AURKA Anticorps)), Aurora B (AURKB (Montrer AURKB Anticorps)) and Aurora C (AURKC summarize their involvement in leukemia and discuss inhibitor development and efficacy in leukemia clinical trials
Aberrantly expressed Aurora-C in somatic cancer cells may impair spindle checkpoint assembly by displacing the centromeric localization of chromosomal passenger complexes.
Our data indicate that the AURKC c.144delC mutation has a relatively high carrier frequency in the Moroccan population.
The high sequence similarity among the AURK family members has made discerning the individual kinase functions in meiosis challenging. Technical limitations in specifically targeting AURKB (Montrer AURKB Anticorps) or AURKC using small-molecule inhibitors and compensatory abilities in single-knockout animals add to this challenge...proper regulation of AURKA (Montrer AURKA Anticorps) expression is crucial for spindle formation in meiosis
Three of these mutations AURKC c.144delC (AURKC p.L49Wfs22), AURKC c.686G > A (AURKC p.C229Y) and AURKC c.744C > G (AURKC p.Y248*) are the focus of this study. AURKC p.L49Wfs22 is a loss-of-function mutant that perturbs localization of the chromosomal passenger complex (CPC), AURKC p.C229Y is a hypomorph that cannot fully support cell-cycle progression, and AURKC p.Y248* fails to support chromosome segregation.
These data uncover a role for haspin (Montrer GSG2 Anticorps) as a regulator of bipolar spindle assembly by regulating AURKC function at acentriolar microtubule-organizing centers in oocytes.
these data suggest that mammalian oocytes contain AURKC to efficiently execute meiosis I and ensure high-quality eggs necessary for sexual reproduction.
These findings suggest a model for the presence of AURKC in oocytes: that AURKC compensates for loss of AURKB (Montrer AURKB Anticorps) through differences in both message recruitment and protein stability.
Overexpressed Aurora-C (aurkc) is an oncogene (Montrer RAB1A Anticorps). Overexpression of Aurora-C induces abnormal cell division resulting in centrosome amplification and multinucleation. Cells overexpressing active Aurora-C induced tumour formation.
Conditional deletion of aurora B in somatic cells that do not express aurora C results in chromosomal misalignment and lack of chromosome segregation.
Aurora-C, but not Aurora-B, plays essential roles in female mouse meiosis.
role in regulating the cleavage furrow-specific vimentin (Montrer VIM Anticorps) phosphorylation in the cytokinetic process
INCENP (Montrer INCENP Anticorps) recruits Aurora-C (or some other factor(s) recruit INCENP (Montrer INCENP Anticorps) and Aurora-C) to meiotic chromosomes, while Aurora-C may either work alone or cooperate with Aurora-B to regulate chromosome segregation during male meiosis
AURKB (Montrer AURKB Anticorps), AURKC, and Thr (Montrer TRH Anticorps)-phosphorylated AURKA (Montrer AURKA Anticorps) were detected at a contractile ring/midbody during the first polar body extrusion.
This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during mitosis. This gene is overexpressed in several cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants.
aurora kinase C
, aurora 3
, aurora-related kinase 3
, aurora/IPL1-related kinase 3
, aurora/IPL1/EG2 protein 2
, serine/threonine kinase 13 (aurora/IPL1-like)
, serine/threonine-protein kinase 13
, serine/threonine-protein kinase aurora-C
, aurora B
, aurora/Ipl1/Eg2 protein 1
, serine/threonine kinase 13 (aurora/IPL-like)